AdamTS-A ADAM metallopeptidase with thrombospondin type 1 motif A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: AdamTS-Aprovided by FlyBase
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif Aprovided by FlyBase
Primary source: FLYBASE:FBgn0286071
Locus tag: Dmel_CG14869
See related: AllianceGenome:FB:FBgn0286071
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: ADAMTS-A; CG14869; CG6107; CT19033; Dmel\CG14869; l(3)89Aa; rnwy
Summary: Predicted to enable metalloendopeptidase activity. Involved in several processes, including epithelial cell migration, open tracheal system; larval salivary gland morphogenesis; and mesodermal cell migration. Predicted to be active in extracellular matrix. Is expressed in several structures, including embryonic/larval midgut longitudinal visceral muscle cell; embryonic/larval salivary gland; embryonic/larval visceral tracheal branch; surface glial cell; and visceral mesoderm derivative. Orthologous to several human genes including ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 88F5-88F6; 3-57 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (15442246..15476193, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (11267968..11301915, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In this study, whole genome expression analysis was performed to identify genes activated by JAK/STAT and/or EGFR..AdamTS-A mRNA becomes enriched at the anterior and posterior poles of the egg chamber at stages 6 to 7 and is regulated by JAK/STAT.
Title: A Gene Expression Screen in Drosophila melanogaster Identifies Novel JAK/STAT and EGFR Targets During Oogenesis.
This work supports a model in which AdamTS-A anchors cells in place and preserves central nervous system architecture by reducing tissue stiffness.
Title: The extracellular metalloprotease AdamTS-A anchors neural lineages in place within and preserves the architecture of the central nervous system.
ADAMTS-A detaches salivary gland cells from the apical extracellular matrix.
Title: The secreted AdamTS-A metalloprotease is required for collective cell migration.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epithelial cell migration, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval salivary gland morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesodermal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ADAM metallopeptidase with thrombospondin type 1 motif A

Names: AdamTS-A-PB; AdamTS-A-PC; AdamTS-A-PE; CG14869-PB; CG14869-PC; CG14869-PE; lethal (3) 89Aa; runaway

NP_001262604.1

EC 3.4.24.-

NP_732036.2

EC 3.4.24.-

NP_996218.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

15442246..15476193 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206496.2 → NP_996218.1 ADAM metallopeptidase with thrombospondin type 1 motif A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996218.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8SXB0, Q9VF61

Conserved Domains (7) summary

smart00209
Location:754 → 806

TSP1; Thrombospondin type 1 repeats

cd04273
Location:455 → 655

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:457 → 655

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:286 → 394

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:937 → 1042

ADAM_spacer1; ADAM-TS Spacer 1

pfam08685
Location:1495 → 1687

GON; GON domain

pfam12115
Location:696 → 745

Salp15; Salivary protein of 15kDa inhibits CD4+ T cell activation
NM_001275675.1 → NP_001262604.1 ADAM metallopeptidase with thrombospondin type 1 motif A, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262604.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHK4

Conserved Domains (7) summary

smart00209
Location:651 → 703

TSP1; Thrombospondin type 1 repeats

cd04273
Location:352 → 552

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:354 → 552

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:183 → 291

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:834 → 939

ADAM_spacer1; ADAM-TS Spacer 1

pfam08685
Location:1392 → 1584

GON; GON domain

pfam12115
Location:593 → 642

Salp15; Salivary protein of 15kDa inhibits CD4+ T cell activation
NM_169659.3 → NP_732036.2 ADAM metallopeptidase with thrombospondin type 1 motif A, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732036.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7KSH7

Related

FBpp0308490

Conserved Domains (7) summary

smart00209
Location:603 → 655

TSP1; Thrombospondin type 1 repeats

cd04273
Location:304 → 504

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:306 → 504

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:135 → 243

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:786 → 891

ADAM_spacer1; ADAM-TS Spacer 1

pfam08685
Location:1344 → 1536

GON; GON domain

pfam12115
Location:545 → 594

Salp15; Salivary protein of 15kDa inhibits CD4+ T cell activation