U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    dysc dyschronic [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39533, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    dyscprovided by FlyBase
    Official Full Name
    dyschronicprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264006
    Locus tag
    Dmel_CG43749
    See related
    AllianceGenome:FB:FBgn0264006
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-AE003536.1; CG17368; CG32131; CG32132; CG34400; CG43749; CG8760; Dmel\CG43749; Dm_3L:69335; DYSC
    Old locus tag
    CG17368; CG32131; CG8760; Dmel_CG17368; Dmel_CG32131; Dmel_CG32132; Dmel_CG34400; Dmel_CG8760
    Summary
    Involved in several processes, including locomotor rhythm; muscle cell cellular homeostasis; and neuron development. Located in synapse. Is expressed in several structures, including adult brain; adult head; adult mushroom body; adult pacemaker neurons; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in Usher syndrome type 2D; autosomal recessive nonsyndromic deafness 31; and sensorineural hearing loss. Orthologous to human WHRN (whirlin). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See dysc in Genome Data Viewer
    Location:
    70C5-70C5; 3-41 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13867414..13903236, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13860514..13896336, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Hemolectin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ral guanine nucleotide dissociation stimulator-like Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genetics, pathogenesis and therapeutic developments for Usher syndrome type 2. Stemerdink M, et al. Hum Genet, 2022 Apr. PMID 34331125
    2. Impaired Pre-Motor Circuit Activity and Movement in a Drosophila Model of KCNMA1-Linked Dyskinesia. Kratschmer P, et al. Mov Disord, 2021 May. PMID 33449381, Free PMC Article
    3. Dissecting the Genetic Basis of Variation in Drosophila Sleep Using a Multiparental QTL Mapping Resource. Smith BR, et al. Genes (Basel), 2020 Mar 11. PMID 32168738, Free PMC Article
    4. Antagonistic Regulation of Circadian Output and Synaptic Development by JETLAG and the DYSCHRONIC-SLOWPOKE Complex. Lamaze A, et al. iScience, 2020 Feb 21. PMID 32058958, Free PMC Article
    5. Regulation of synaptic development and function by the Drosophila PDZ protein Dyschronic. Jepson JE, et al. Development, 2014 Dec. PMID 25359729, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dyschronic regulates synaptic development and function at the neuromuscular junction.
      Title: Regulation of synaptic development and function by the Drosophila PDZ protein Dyschronic.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    mobile_element

    • Loc: c13896438-13896388 mobile_element_type = transposon:INE-1{}2782

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle cell cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photoreceptor cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rhabdomere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of stereocilia ankle link complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in stereocilium tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    dyschronic
    Names
    CG43749-PC
    CG43749-PE
    CG43749-PF
    CG43749-PG
    CG43749-PH
    CG43749-PI
    CG43749-PJ
    dysc-PC
    dysc-PE
    dysc-PF
    dysc-PG
    dysc-PH
    dysc-PI
    dysc-PJ

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13867414..13903236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274884.2 → NP_001261813.1  dyschronic, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261813.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PI53
      Conserved Domains (2) summary
      cd00992
      Location:294 → 376
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd07357
      Location:569 → 649
      HN_L-whirlin_R2_like; second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains

    2. NM_001144475.3 → NP_001137947.1  dyschronic, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137947.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z048
      Conserved Domains (2) summary
      cd00992
      Location:294 → 380
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd07357
      Location:573 → 653
      HN_L-whirlin_R2_like; second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains

    3. NM_001274883.2 → NP_001261812.1  dyschronic, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261812.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFF3
      Conserved Domains (2) summary
      cd00992
      Location:294 → 380
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd07357
      Location:573 → 653
      HN_L-whirlin_R2_like; second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains

    4. NM_001274882.2 → NP_001261811.1  dyschronic, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261811.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFJ0
      Conserved Domains (2) summary
      cd00992
      Location:294 → 380
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd07357
      Location:573 → 653
      HN_L-whirlin_R2_like; second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains

    5. NM_140411.5 → NP_648668.3  dyschronic, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648668.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU98
      Conserved Domains (2) summary
      cd00992
      Location:294 → 380
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd07357
      Location:573 → 653
      HN_L-whirlin_R2_like; second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains

    6. NM_001274881.2 → NP_001261810.1  dyschronic, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261810.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF56
      Conserved Domains (2) summary
      cd00992
      Location:294 → 380
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd07357
      Location:573 → 653
      HN_L-whirlin_R2_like; second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains

    7. NM_001144474.3 → NP_001137946.1  dyschronic, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137946.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z049
      Conserved Domains (2) summary
      cd00992
      Location:294 → 380
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd07357
      Location:573 → 653
      HN_L-whirlin_R2_like; second harmonin_N_like domain (repeat 2) of the long isoform of whirlin, and related domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z048 B7Z048
    B7Z049 B7Z049
    M9PF56 M9PF56
    M9PFF3 M9PFF3
    M9PFJ0 M9PFJ0
    M9PI53 M9PI53
    Q9VU98 Q9VU98

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools