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    Ak1 Adenylate kinase 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39396, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ak1provided by FlyBase
    Official Full Name
    Adenylate kinase 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0022709
    Locus tag
    Dmel_CG17146
    See related
    AllianceGenome:FB:FBgn0022709
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ADK-1; adk1; Adk1; AK1; bs34e10.y1; CG17146; Dak1; DAK1; Dmel\CG17146
    Summary
    Enables adenylate kinase activity. Predicted to be involved in 'de novo' pyrimidine nucleobase biosynthetic process. Predicted to be located in nucleus. Predicted to be active in cytosol. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia and hemolytic anemia. Orthologous to human AK1 (adenylate kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ak1 in Genome Data Viewer
    Location:
    69A2-69A2; 3-38 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12200322..12204082, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12193422..12197182, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45746 Neighboring gene uncharacterized protein Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene approximated Neighboring gene long non-coding RNA:CR43991

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and chromosomal mapping of the gene encoding adenylate kinase 2 from Drosophila melanogaster. Noma T, et al. Biochim Biophys Acta, 2000 Jan 31. PMID 10786623
    2. Adenylate kinase isozyme 2 is essential for growth and development of Drosophila melanogaster. Fujisawa K, et al. Comp Biochem Physiol B Biochem Mol Biol, 2009 May. PMID 19416704
    3. Forward and reverse selection for longevity in Drosophila is characterized by alteration of antioxidant gene expression and oxidative damage patterns. Arking R, et al. Exp Gerontol, 2000 Mar. PMID 10767577
    4. Identical longevity phenotypes are characterized by different patterns of gene expression and oxidative damage. Arking R, et al. Exp Gerontol, 2000 May. PMID 10832056
    5. Does segregating variation in sexual or microhabitat preferences lead to non-random mating within a population of Drosophila melanogaster? Foley BR, et al. Biol Lett, 2010 Feb 23. PMID 19692395, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UMP/dUMP kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables adenylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ATP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleobase-containing compound metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    adenylate kinase 1
    Names
    Ak1-PA
    Ak1-PB
    CG17146-PA
    CG17146-PB
    adenylate kinase-1
    NP_524038.1
    NP_729792.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12200322..12204082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168493.2 → NP_729792.1  adenylate kinase 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729792.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IQG9, Q9VTV3
      Related
      FBpp0075750
      Conserved Domains (2) summary
      TIGR01360
      Location:30 → 217
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
      cd01428
      Location:34 → 206
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...

    2. NM_079314.3 → NP_524038.1  adenylate kinase 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524038.1

      Status: REVIEWED

      Related
      FBpp0075749
      Conserved Domains (2) summary
      TIGR01360
      Location:2 → 189
      aden_kin_iso1; adenylate kinase, isozyme 1 subfamily
      cd01428
      Location:6 → 178
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQG9 Q8IQG9
    Q9VTV3 Q9VTV3

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