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    CG18586 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38659, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG18586provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035642
    Locus tag
    Dmel_CG18586
    See related
    AllianceGenome:FB:FBgn0035642
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG18586
    Summary
    Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in fatty-acyl-CoA biosynthetic process and long-chain fatty acid metabolic process. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG18586 in Genome Data Viewer
    Location:
    64F3-64F3; 3-15 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5873311..5875466)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5866411..5868566)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene krishah Neighboring gene mad2 Neighboring gene vein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene DNA polymerase epsilon subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Firefly luciferase: an adenylate-forming enzyme for multicatalytic functions. Inouye S. Cell Mol Life Sci, 2010 Feb. PMID 19859663, Free PMC Article
    2. Characterization of CG6178 gene product with high sequence similarity to firefly luciferase in Drosophila melanogaster. Oba Y, et al. Gene, 2004 Mar 31. PMID 15033536
    3. Enzymatic and genetic characterization of firefly luciferase and Drosophila CG6178 as a fatty acyl-CoA synthetase. Oba Y, et al. Biosci Biotechnol Biochem, 2005 Apr. PMID 15849423
    4. Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits. Durham MF, et al. Nat Commun, 2014 Jul 8. PMID 25000897
    5. Latitudinal clines in gene expression and cis-regulatory element variation in Drosophila melanogaster. Juneja P, et al. BMC Genomics, 2016 Nov 28. PMID 27894253, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables long-chain fatty acid-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty-acyl-CoA biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG18586-PB
    CG18586-PC
    NP_001261453.1
    NP_647993.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5873311..5875466
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274524.1 → NP_001261453.1  uncharacterized protein Dmel_CG18586, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261453.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEA1
      Conserved Domains (2) summary
      COG0318
      Location:52 → 532
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
      cl17068
      Location:55 → 521
      AFD_class_I; Adenylate forming domain, Class I superfamily

    2. NM_139736.2 → NP_647993.2  uncharacterized protein Dmel_CG18586, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647993.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V535, Q9VRQ5
      Conserved Domains (2) summary
      COG0318
      Location:35 → 541
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
      cl17068
      Location:55 → 530
      AFD_class_I; Adenylate forming domain, Class I superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PEA1 M9PEA1
    Q9VRQ5 Q9VRQ5

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