U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Uev1A Ubiquitin-conjugating enzyme variant 1A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38613, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Uev1Aprovided by FlyBase
    Official Full Name
    Ubiquitin-conjugating enzyme variant 1Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035601
    Locus tag
    Dmel_CG10640
    See related
    AllianceGenome:FB:FBgn0035601
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10640; Dmel\CG10640; DmUEV; DmUev1a; dUev1A; dUEV1a; dUEV1A; UEV; uev1a; Uev1a; UEV1a; UEV1A
    Summary
    Enables ubiquitin conjugating enzyme binding activity. Involved in peptidoglycan recognition protein signaling pathway; positive regulation of signal transduction; and protein polyubiquitination. Part of UBC13-MMS2 complex. Is expressed in several structures, including adult head; adult heart; anterior endoderm anlage; germline cell; and mesoderm. Orthologous to several human genes including UBE2V2 (ubiquitin conjugating enzyme E2 V2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Uev1A in Genome Data Viewer
    Location:
    64C13-64C13; 3-13 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5362884..5366225, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5355984..5359325, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Kinesin-like protein at 64D Neighboring gene Cytochrome c1 Neighboring gene membrin Neighboring gene Prefoldin 4 Neighboring gene long non-coding RNA:CR44515

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Drosophila Uev1a is dually required for Ben-dependent DNA-damage response and fly mobility. Bai Z, et al. Cell Signal, 2020 Oct. PMID 32702441
    2. Drosophila bendless catalyzes K63-linked polyubiquitination and is involved in the response to DNA damage. Bai Z, et al. Mutat Res, 2018 Mar. PMID 29518634
    3. Drosophila Argonaute2 turnover is regulated by the ubiquitin proteasome pathway. Chinen M, et al. Biochem Biophys Res Commun, 2017 Feb 12. PMID 28087276, Free PMC Article
    4. Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways. Herman-Bachinsky Y, et al. Cell Death Differ, 2007 Apr. PMID 17205079
    5. Innate immune signaling in Drosophila is regulated by transforming growth factor β (TGFβ)-activated kinase (Tak1)-triggered ubiquitin editing. Chen L, et al. J Biol Chem, 2017 May 26. PMID 28377500, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila Uev1a is dually required for Ben-dependent DNA-damage response and fly mobility.
      Title: Drosophila Uev1a is dually required for Ben-dependent DNA-damage response and fly mobility.
    2. data indicate that dUev1a encodes an essential component of the evolutionary conserved TNF-JNK signaling pathway that modulates tumor progression and cell death in metazoan
      Title: dUev1a modulates TNF-JNK mediated tumor progression and cell death in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of positive regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of positive regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of tumor necrosis factor-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K63-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of UBC13-MMS2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin conjugating enzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Ubiquitin-conjugating enzyme
    Names
    CG10640-PA
    CG10640-PB
    CG10640-PC
    Uev1A-PA
    Uev1A-PB
    Uev1A-PC

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5362884..5366225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168117.3 → NP_729062.1  Ubiquitin-conjugating enzyme variant 1A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729062.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQ53
      Related
      FBpp0076860
      Conserved Domains (1) summary
      smart00212
      Location:2 → 100
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    2. NM_001300011.1 → NP_001286940.1  Ubiquitin-conjugating enzyme variant 1A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286940.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGH9, Q9VRL1
      Conserved Domains (1) summary
      smart00212
      Location:16 → 142
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

    3. NM_139702.4 → NP_647959.1  Ubiquitin-conjugating enzyme variant 1A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647959.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGH9, Q9VRL1
      Related
      FBpp0076859
      Conserved Domains (1) summary
      smart00212
      Location:16 → 142
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGH9 Q8IGH9
    Q8IQ53 Q8IQ53
    Q9VRL1 Q9VRL1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous