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    ND-19 NADH dehydrogenase (ubiquinone) 19 kDa subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37946, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ND-19provided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) 19 kDa subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035046
    Locus tag
    Dmel_CG3683
    See related
    AllianceGenome:FB:FBgn0035046
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3683; Dmel\CG3683; dNDUFA8; ND19; Ndufa8; NDUFA8; NUPM; Q9W125; RH23043p
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut primordium; larval muscle cell; and mesoderm. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency. Orthologous to human NDUFA8 (NADH:ubiquinone oxidoreductase subunit A8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ND-19 in Genome Data Viewer
    Location:
    60D13-60D13; 2-107 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24664398..24665439)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20551921..20552962)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cuticular protein 60D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila. Gospodaryov DV, et al. Biochim Biophys Acta, 2014 Nov. PMID 25124484
    2. Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction. Sanz A, et al. Proc Natl Acad Sci U S A, 2010 May 18. PMID 20435911, Free PMC Article
    3. Practical Recommendations for the Use of the GeneSwitch Gal4 System to Knock-Down Genes in Drosophila melanogaster. Scialo F, et al. PLoS One, 2016. PMID 27570965, Free PMC Article
    4. Aconitase causes iron toxicity in Drosophila pink1 mutants. Esposito G, et al. PLoS Genet, 2013 Apr. PMID 23637640, Free PMC Article
    5. Mitochondrial electron transport chain defects modify Parkinson's disease phenotypes in a Drosophila model. O'Hanlon ME, et al. Neurobiol Dis, 2022 Sep. PMID 35764292

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial electron transport, NADH to ubiquinone IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) 19 kDa subunit
    Names
    CG3683-PA
    CG3683-PB
    CG3683-PC
    CG3683-PD
    FBpp0072231
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8
    NADH ubiquinone oxidoreductase 19 kDa
    NADH-UBIQUINONE OXIDOREDUCTASE 19 KDA SUBUNIT
    NADH:ubiquinone oxidoreductase 19 kDa subunit
    ND-19-PA
    ND-19-PB
    ND-19-PC
    ND-19-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24664398..24665439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138110.4 → NP_611954.2  NADH dehydrogenase (ubiquinone) 19 kDa subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611954.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SY88, Q9W125
      Related
      FBpp0072231
      Conserved Domains (1) summary
      pfam06747
      Location:80 → 116
      CHCH; CHCH domain

    2. NM_166681.2 → NP_726471.1  NADH dehydrogenase (ubiquinone) 19 kDa subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726471.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SY88, Q9W125
      Related
      FBpp0072233
      Conserved Domains (1) summary
      pfam06747
      Location:80 → 116
      CHCH; CHCH domain

    3. NM_166680.3 → NP_726470.1  NADH dehydrogenase (ubiquinone) 19 kDa subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726470.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SY88, Q9W125
      Related
      FBpp0072232
      Conserved Domains (1) summary
      pfam06747
      Location:80 → 116
      CHCH; CHCH domain

    4. NM_001169825.2 → NP_001163296.1  NADH dehydrogenase (ubiquinone) 19 kDa subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163296.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SY88, Q9W125
      Conserved Domains (1) summary
      pfam06747
      Location:80 → 116
      CHCH; CHCH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SY88 Q8SY88
    Q9W125 Q9W125

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