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    sona sol narae [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37762, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sonaprovided by FlyBase
    Official Full Name
    sol naraeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034903
    Locus tag
    Dmel_CG9850
    See related
    AllianceGenome:FB:FBgn0034903
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11169; CG9850; dimp; Dimp; Dmel\CG9850; Sona
    Summary
    Enables metalloendopeptidase activity. Involved in imaginal disc-derived appendage development; positive regulation of cell communication; and proteolysis. Located in Golgi-associated vesicle; endosome; and extracellular exosome. Is expressed in several structures, including imaginal disc; ommatidium; presumptive femur; presumptive tibia; and presumptive unguis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sona in Genome Data Viewer
    Location:
    59F7-60A1; 2-104 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23753477..23798395, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19641000..19685918, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An ADAMTS Sol narae is required for cell survival in Drosophila. Tsogtbaatar O, et al. Sci Rep, 2019 Feb 4. PMID 30718556, Free PMC Article
    2. Wg secreted by conventional Golgi transport diffuses and forms Wg gradient whereas Wg tethered to extracellular vesicles do not diffuse. Won JH, et al. Cell Death Differ, 2021 Mar. PMID 33028960, Free PMC Article
    3. Anastral Spindle 3/Rotatin Stabilizes Sol narae and Promotes Cell Survival in Drosophila melanogaster. Cho DG, et al. Mol Cells, 2021 Jan 31. PMID 33510049, Free PMC Article
    4. Exosomal arrow (Arr)/lipoprotein receptor protein 6 (LRP6) in Drosophila melanogaster increases the extracellular level of Sol narae (Sona) in a Wnt-independent manner. Han JH, et al. Cell Death Dis, 2020 Nov 3. PMID 33139721, Free PMC Article
    5. POU domain motif3 (Pdm3) induces wingless (wg) transcription and is essential for development of larval neuromuscular junctions in Drosophila. Kim Y, et al. Sci Rep, 2020 Jan 16. PMID 31949274, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Anastral Spindle 3/Rotatin Stabilizes Sol narae and Promotes Cell Survival in Drosophila melanogaster.
      Title: Anastral Spindle 3/Rotatin Stabilizes Sol narae and Promotes Cell Survival in Drosophila melanogaster.
    2. An ADAMTS Sol narae is required for cell survival in Drosophila.
      Title: An ADAMTS Sol narae is required for cell survival in Drosophila.
    3. Sona generates Wg C-terminal domain that carries out subsets of Wg signaling.
      Title: ADAMTS Sol narae cleaves extracellular Wingless to generate a novel active form that regulates cell proliferation in Drosophila.
    4. This study suggests that Sona is involved in Wg signaling by regulating the level of extracellular Wg.
      Title: Sol narae (Sona) is a Drosophila ADAMTS involved in Wg signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in imaginal disc-derived appendage development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membrane protein ectodomain proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Wnt protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi-associated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sol narae
    Names
    CG9850-PA
    CG9850-PC
    CG9850-PD
    CG9850-PE
    CG9850-PF
    Dlg-interacting metalloprotease
    sona-PA
    sona-PC
    sona-PD
    sona-PE
    sona-PF
    NP_001027572.2
    NP_001137746.1
    NP_001261157.1
    NP_001261158.1
    NP_611827.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23753477..23798395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144274.3 → NP_001137746.1  sol narae, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137746.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZP6
      Conserved Domains (1) summary
      cd04272
      Location:313 → 542
      ZnMc_salivary_gland_MPs; Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.

    2. NM_137983.5 → NP_611827.2  sol narae, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611827.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W1J9
      Conserved Domains (1) summary
      cd04272
      Location:313 → 542
      ZnMc_salivary_gland_MPs; Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.

    3. NM_001274229.2 → NP_001261158.1  sol narae, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261158.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGD6
      Conserved Domains (1) summary
      cd04272
      Location:313 → 541
      ZnMc_salivary_gland_MPs; Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.

    4. NM_001032400.3 → NP_001027572.2  sol narae, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001027572.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2MGN5
      Conserved Domains (1) summary
      cd04272
      Location:313 → 541
      ZnMc_salivary_gland_MPs; Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.

    5. NM_001274228.2 → NP_001261157.1  sol narae, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261157.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFG8
      Conserved Domains (1) summary
      cd04272
      Location:313 → 541
      ZnMc_salivary_gland_MPs; Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFG8 A0A0B4KFG8
    A0A0B4KGD6 A0A0B4KGD6
    B7YZP6 B7YZP6
    Q2MGN5 Q2MGN5
    Q8MT72 Q8MT72
    Q9W1J9 Q9W1J9

    Gene LinkOut

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