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    gas gasoline [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37572, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gasprovided by FlyBase
    Official Full Name
    gasolineprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034736
    Locus tag
    Dmel_CG6018
    See related
    AllianceGenome:FB:FBgn0034736
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    alphaE1-O; CG6018; DmalphaE1-O; Dmel\CG6018
    Summary
    Enables serine hydrolase activity. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to several human genes including CES1 (carboxylesterase 1); CES2 (carboxylesterase 2); and CES3 (carboxylesterase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gas in Genome Data Viewer
    Location:
    58E8-58E8; 2-100 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22550094..22552113)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18437599..18439618)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene plexus Neighboring gene uncharacterized protein Neighboring gene defense repressor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reconstructing the diversification of alpha-esterases: comparing the gene clusters of Drosophila buzzatii and D. melanogaster. de Q Robin GC, et al. J Mol Evol, 2000 Aug. PMID 10948271
    2. Jouvence a small nucleolar RNA required in the gut extends lifespan in Drosophila. Soulé S, et al. Nat Commun, 2020 Feb 20. PMID 32080190, Free PMC Article
    3. Transcriptional dynamics elicited by a short pulse of notch activation involves feed-forward regulation by E(spl)/Hes genes. Housden BE, et al. PLoS Genet, 2013. PMID 23300480, Free PMC Article
    4. Direct response to Notch activation: signaling crosstalk and incoherent logic. Krejcí A, et al. Sci Signal, 2009 Jan 27. PMID 19176515
    5. Adaptation to Chronic Nutritional Stress Leads to Reduced Dependence on Microbiota in Drosophila melanogaster. Erkosar B, et al. mBio, 2017 Oct 24. PMID 29066546, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carboxylesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables serine hydrolase activity HDA PubMed 

    General protein information

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    Preferred Names
    gasoline
    Names
    CG6018-PA
    gas-PA
    orphan alpha-esterase
    NP_611678.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22550094..22552113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137834.3 → NP_611678.1  gasoline [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611678.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IGQ2, Q9W243
      Related
      FBpp0071746
      Conserved Domains (2) summary
      COG0657
      Location:117 → 222
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:28 → 534
      COesterase; Carboxylesterase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGQ2 Q8IGQ2
    Q9W243 Q9W243

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