fsd fates-shifted [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: fsdprovided by FlyBase
Official Full Name: fates-shiftedprovided by FlyBase
Primary source: FLYBASE:FBgn0033813
Locus tag: Dmel_CG12765
See related: AllianceGenome:FB:FBgn0033813
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12765; Dmel\CG12765; FBXO14
Summary: Enables ubiquitin-like ligase-substrate adaptor activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; anterior/posterior pattern specification; and larval lymph gland hemopoiesis. Part of SCF ubiquitin ligase complex. Is expressed in organism. Orthologous to human TMEM183A (transmembrane protein 183A) and TMEM183BP (transmembrane protein 183B, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (13230583..13231663)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (9118088..9119168)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Data show that the addition of dsRNA targeting the fates-shifted (fsd, CG12765) gene caused a consistent increase in the total amount of Bcd.
Title: Fates-shifted is an F-box protein that targets Bicoid for degradation and regulates developmental fate determination in Drosophila embryos.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISM Inferred from Sequence Model more info
involved_in anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval lymph gland hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of SCF ubiquitin ligase complex	ISM Inferred from Sequence Model more info