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    Plzf Promyelocytic leukemia zinc finger [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34622, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plzfprovided by FlyBase
    Official Full Name
    Promyelocytic leukemia zinc fingerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032401
    Locus tag
    Dmel_CG6792
    See related
    AllianceGenome:FB:FBgn0032401
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg6792; CG6792; Dmel\CG6792; dPLZF; PLZF
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in Ras protein signal transduction and imaginal disc-derived wing vein specification. Predicted to be active in nucleus. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Plzf in Genome Data Viewer
    Location:
    33B11-33B11; 2-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12046711..12048918, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12046711..12048918, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44589 Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol-specific phospholipase C X domain containing Neighboring gene Juvenile hormone Inducible-21 Neighboring gene Ribosomal protein L7-like Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Broad-complex, tramtrack, and bric-à-brac (BTB) proteins: Critical regulators of development. Chaharbakhshi E, et al. Genesis, 2016 Oct. PMID 27521773
    2. The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology, and Influences Locomotor Activity in Drosophila Larvae. Ziegler AB, et al. Sci Rep, 2016 Jan 25. PMID 26805723, Free PMC Article
    3. New candidate genes for heat resistance in Drosophila melanogaster are regulated by HSF. Jensen LT, et al. Cell Stress Chaperones, 2008 Summer. PMID 18759003, Free PMC Article
    4. The BTB/POZ-ZF transcription factor dPLZF is involved in Ras/ERK signaling during Drosophila wing development. Maeng O, et al. Mol Cells, 2012 May. PMID 22544070, Free PMC Article
    5. Drosophila BTB/POZ domains of "ttk group" can form multimers and selectively interact with each other. Bonchuk A, et al. J Mol Biol, 2011 Sep 23. PMID 21821048

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing vein specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    promyelocytic leukemia zinc finger
    Names
    CG6792-PA
    CG6792-PB
    Plzf-PA
    Plzf-PB
    promyelocytic leukemia zinc finger ortholog

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12046711..12048918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298933.1 → NP_001285862.1  promyelocytic leukemia zinc finger, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285862.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TH6, Q9VKC4
      Conserved Domains (2) summary
      COG5048
      Location:193 → 403
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:244 → 264
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_135696.3 → NP_609540.2  promyelocytic leukemia zinc finger, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609540.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TH6, Q9VKC4
      Related
      FBpp0079889
      Conserved Domains (2) summary
      COG5048
      Location:193 → 403
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:244 → 264
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TH6 Q95TH6
    Q9VKC4 Q9VKC4

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