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    senju senju [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33734, updated on 17-Dec-2024

    Summary

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    Official Symbol
    senjuprovided by FlyBase
    Official Full Name
    senjuprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031676
    Locus tag
    Dmel_CG14040
    See related
    AllianceGenome:FB:FBgn0031676
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14040; Dmel\CG14040
    Summary
    Enables UDP-galactose transmembrane transporter activity. Involved in several processes, including UDP-galactose transmembrane transport; negative regulation of Toll signaling pathway; and positive regulation of macromolecule biosynthetic process. Located in Golgi medial cisterna. Is expressed in adult head. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See senju in Genome Data Viewer
    Location:
    25C3-25C3; 2-15 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5052843..5054575)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5052843..5054575)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene SP555 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 3 subunit h Neighboring gene uncharacterized protein Neighboring gene Histone H3.3A Neighboring gene Neprilysin-like 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression of a functional Drosophila melanogaster N-acetylneuraminic acid (Neu5Ac) phosphate synthase gene: evidence for endogenous sialic acid biosynthetic ability in insects. Kim K, et al. Glycobiology, 2002 Feb. PMID 11886840
    2. Cisterna-specific localization of glycosylation-related proteins to the Golgi apparatus. Yamamoto-Hino M, et al. Cell Struct Funct, 2012. PMID 22251795
    3. Dynamic regulation of innate immune responses in Drosophila by Senju-mediated glycosylation. Yamamoto-Hino M, et al. Proc Natl Acad Sci U S A, 2015 May 5. PMID 25901322, Free PMC Article
    4. The Proton-Coupled Monocarboxylate Transporter Hermes Is Necessary for Autophagy during Cell Death. Velentzas PD, et al. Dev Cell, 2018 Nov 5. PMID 30318245, Free PMC Article
    5. Meigo governs dendrite targeting specificity by modulating ephrin level and N-glycosylation. Sekine SU, et al. Nat Neurosci, 2013 Jun. PMID 23624514, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables UDP-galactose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-galactose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyrimidine nucleotide-sugar transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-galactose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of Toll signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antimicrobial peptide production IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pyrimidine nucleotide-sugar transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi medial cisterna IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    senju
    Names
    CG14040-PA
    senju-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5052843..5054575
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135058.4 → NP_608902.1  senju [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608902.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MYZ6, Q9VMU8
      Related
      FBpp0078648
      Conserved Domains (1) summary
      pfam04142
      Location:44 → 346
      Nuc_sug_transp; Nucleotide-sugar transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMU8.2 Q9VMU8

    Gene LinkOut

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