Amnionless amnionless [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Amnionlessprovided by FlyBase
Official Full Name: amnionlessprovided by FlyBase
Primary source: FLYBASE:FBgn0025686
Locus tag: Dmel_CG11592
See related: AllianceGenome:FB:FBgn0025686
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Amn; BEST:CK02467; CG11592; CK02467; dAmn; dAMN; Dmel\CG11592
Summary: Enables cargo receptor activity. Involved in clathrin-dependent endocytosis; nephrocyte filtration; and renal protein absorption. Part of receptor complex. Is expressed in adult head; adult heart; garland cell primordium; nephrocyte; and visceral mesoderm derivative. Used to study cardiomyopathy and kidney disease. Human ortholog(s) of this gene implicated in megaloblastic anemia. Orthologous to human AMN (amnion associated transmembrane protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (287252..289144, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (287252..289144, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cargo receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nephrocyte filtration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor-mediated endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in renal protein absorption	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
part_of receptor complex	IPI Inferred from Physical Interaction more info	PubMed