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    CG42450 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32874, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG42450provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259927
    Locus tag
    Dmel_CG42450
    See related
    AllianceGenome:FB:FBgn0259927
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32543; CG7095; Dmel\CG42450
    Old locus tag
    Dmel_CG32543; Dmel_CG7095
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in G protein-coupled dopamine receptor signaling pathway. Predicted to be active in cytoplasm; neuron projection; and plasma membrane. Is expressed in adult head and spermatozoon. Human ortholog(s) of this gene implicated in bradyopsia 1. Orthologous to several human genes including RGS9 (regulator of G protein signaling 9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG42450 in Genome Data Viewer
    Location:
    17E1-17E1; 1-61 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18813297..18830406)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18707330..18724439)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene S6 Kinase Like Neighboring gene antisense RNA:CR44841 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene PDGF- and VEGF-related factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Splicing repression is a major function of TDP-43 in motor neurons. Donde A, et al. Acta Neuropathol, 2019 Nov. PMID 31332509, Free PMC Article
    2. A genetic screen for suppressors of Drosophila NSF2 neuromuscular junction overgrowth. Laviolette MJ, et al. Genetics, 2005 Jun. PMID 15834148, Free PMC Article
    3. Growth deregulation and interaction with host hemocytes contribute to tumor progression in a Drosophila brain tumor model. Voutyraki C, et al. Proc Natl Acad Sci U S A, 2023 Aug 15. PMID 37549261, Free PMC Article
    4. Genetic atlas of hygro-and thermosensory cells in the vinegar fly Drosophila melanogaster. Corthals K, et al. Sci Rep, 2023 Sep 14. PMID 37709909, Free PMC Article
    5. Genome-wide identification and characterization of tissue-specific RNA editing events in D. melanogaster and their potential role in regulating alternative splicing. Mazloomian A, et al. RNA Biol, 2015. PMID 26512413, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled dopamine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG42450-PA
    CG42450-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18813297..18830406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272762.2 → NP_001259691.1  uncharacterized protein Dmel_CG42450, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259691.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHI8
      Conserved Domains (3) summary
      cd08705
      Location:494 → 614
      RGS_R7-like; Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins
      cd04450
      Location:219 → 306
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam00631
      Location:422 → 482
      G-gamma; GGL domain

    2. NM_133100.4 → NP_573328.2  uncharacterized protein Dmel_CG42450, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573328.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWP8
      Conserved Domains (3) summary
      cd08705
      Location:494 → 614
      RGS_R7-like; Regulator of G protein signaling (RGS) domain found in the R7 subfamily of proteins
      cd04450
      Location:219 → 306
      DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
      pfam00631
      Location:422 → 482
      G-gamma; GGL domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHI8 M9PHI8
    Q9VWP8 Q9VWP8

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