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    upd3 unpaired 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3346149, updated on 9-Dec-2024

    Summary

    Official Symbol
    upd3provided by FlyBase
    Official Full Name
    unpaired 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0053542
    Locus tag
    Dmel_CG33542
    See related
    AllianceGenome:FB:FBgn0053542
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg15062; CG15062; CG15062/CG5963; CG33542; cg5963; CG5963; Dmel\CG33542; od; odsy; os; sy; Unpaireds; upd; Upd; upd 3; upd-3; Upd-3; Upd-like; Upd3; UPD3
    Summary
    Enables cytokine activity. Involved in several processes, including intestinal epithelial structure maintenance; intestinal stem cell homeostasis; and lamellocyte differentiation. Located in extracellular space. Is expressed in several structures, including adult anal pad; cortical zone of lymph gland primary lobe; cuboidal/columnar epithelium; dorsal mesothoracic pleura primordium; and gut section. Used to study cancer. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See upd3 in Genome Data Viewer
    Location:
    17A4-17A4; 1-60 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18277233..18284596)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18171266..18178629)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45613 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR15061 Neighboring gene unpaired 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    PubMed 

    General protein information

    Preferred Names
    unpaired 3
    Names
    CG33542-PB
    Unpaired3
    Upd3
    outstretched
    outstretched-smalleye
    small-eye
    unpaired
    unpaired 3beta
    unpaired-3
    unpaired-3.3
    unpaired-like protein 3
    upd homolog
    upd3-PB

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18277233..18284596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103544.2NP_001097014.1  unpaired 3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097014.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q059C5, Q59E38
      Conserved Domains (1) summary
      pfam15972
      Location:100393
      Unpaired; Unpaired protein