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    Prosbeta2R1 Proteasome beta2 subunit-related 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31511, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Prosbeta2R1provided by FlyBase
    Official Full Name
    Proteasome beta2 subunit-related 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0029812
    Locus tag
    Dmel_CG18341
    See related
    AllianceGenome:FB:FBgn0029812
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    beta2R1; CG18341; Dmel\CG18341
    Summary
    Predicted to enable endopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in proteosome-associated autoinflammatory syndrome 5. Orthologous to several human genes including PSMB7 (proteasome 20S subunit beta 7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Prosbeta2R1 in Genome Data Viewer
    Location:
    5C2-5C2; 1-14 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5808954..5810158)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5702987..5704191)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cuticular protein 5C Neighboring gene long non-coding RNA:CR45529 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular evolution of sex-biased genes in the Drosophila ananassae subgroup. Grath S, et al. BMC Evol Biol, 2009 Dec 16. PMID 20015359, Free PMC Article
    2. Proteasome α6 Subunit Negatively Regulates the JAK/STAT Pathway and Blood Cell Activation in Drosophila melanogaster. Järvelä-Stölting M, et al. Front Immunol, 2021. PMID 35003057, Free PMC Article
    3. Expression of proteasome subunit isoforms during spermatogenesis in Drosophila melanogaster. Ma J, et al. Insect Mol Biol, 2002 Dec. PMID 12421421
    4. Duplicated proteasome subunit genes in Drosophila and their roles in spermatogenesis. Belote JM, et al. Heredity (Edinb), 2009 Jul. PMID 19277057
    5. Loss of the starvation-induced gene Rack1 leads to glycogen deficiency and impaired autophagic responses in Drosophila. Erdi B, et al. Autophagy, 2012 Jul 1. PMID 22562043, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables threonine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome core complex, beta-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    proteasome beta2 subunit-related 1
    Names
    CG18341-PA
    Prosbeta2R1-PA
    proteasome beta2R1 subunit
    NP_572267.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5808954..5810158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132039.3 → NP_572267.1  proteasome beta2 subunit-related 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572267.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B4F5B0, C0ML85, Q86NT6, Q9W470
      Related
      FBpp0070782
      Conserved Domains (3) summary
      TIGR03690
      Location:48 → 241
      20S_bact_beta; proteasome, beta subunit, bacterial type
      cd03763
      Location:49 → 236
      proteasome_beta_type_7; proteasome beta type-7 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
      pfam12465
      Location:241 → 274
      Pr_beta_C; Proteasome beta subunits C terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86NT6 Q86NT6
    Q9W470 Q9W470

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