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    T3dh Type III alcohol dehydrogenase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37551, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T3dhprovided by FlyBase
    Official Full Name
    Type III alcohol dehydrogenaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0017482
    Locus tag
    Dmel_CG3425
    See related
    AllianceGenome:FB:FBgn0017482
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3425; Dmel\CG3425
    Summary
    Predicted to enable alcohol dehydrogenase (NAD+) activity and hydroxyacid-oxoacid transhydrogenase activity. Predicted to be involved in glutamate catabolic process via 2-hydroxyglutarate. Predicted to be active in mitochondrion. Orthologous to human ADHFE1 (alcohol dehydrogenase iron containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See T3dh in Genome Data Viewer
    Location:
    58D3-58D3; 2-99 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22329726..22332072, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18217231..18219577, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44756 Neighboring gene Gp150 Neighboring gene uncharacterized protein Neighboring gene Liprin-gamma Neighboring gene uncharacterized protein Neighboring gene polar granule component Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Diversity and Evolutionary Analysis of Iron-Containing (Type-III) Alcohol Dehydrogenases in Eukaryotes. Gaona-López C, et al. PLoS One, 2016. PMID 27893862, Free PMC Article
    2. Evolutionary conservation of the leucine-rich repeat transmembrane protein Gp150 in Drosophila and Bombyx. Dhulkotia D, et al. Dev Genes Evol, 2000 Mar. PMID 11180815
    3. Speculations on the subject of alcohol dehydrogenase and its properties in Drosophila and other flies. Ashburner M. Bioessays, 1998 Nov. PMID 9872061
    4. Three Drosophila liprins interact to control synapse formation. Astigarraga S, et al. J Neurosci, 2010 Nov 17. PMID 21084592, Free PMC Article
    5. Requirement for a noncoding RNA in Drosophila polar granules for germ cell establishment. Nakamura A, et al. Science, 1996 Dec 20. PMID 8953037

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyacid-oxoacid transhydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutamate catabolic process via 2-hydroxyglutarate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    type III alcohol dehydrogenase
    Names
    CG3425-PA
    T3dh-PA
    NP_477209.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22329726..22332072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057861.3 → NP_477209.2  type III alcohol dehydrogenase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477209.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SX03, Q95S86, Q9W265
      UniProtKB/TrEMBL
      C0PV71
      Related
      FBpp0071759
      Conserved Domains (1) summary
      cd08190
      Location:48 → 461
      HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94532 Q94532
    Q9W265.1 Q9W265

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