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    kek2 kekkon 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34582, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kek2provided by FlyBase
    Official Full Name
    kekkon 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0015400
    Locus tag
    Dmel_CG4977
    See related
    AllianceGenome:FB:FBgn0015400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4977; CT15962; Dmel\CG4977; kek-2; Kek2; NB7
    Summary
    Predicted to be located in plasma membrane. Is expressed in several structures, including head; larval peripheral nervous system; larval ventral nerve cord; presumptive embryonic/larval peripheral nervous system; and ventral midline of embryo. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See kek2 in Genome Data Viewer
    Location:
    32F3-32F4; 2-44 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11581937..11626883)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11581937..11626883)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44494 Neighboring gene long non-coding RNA:CR44495 Neighboring gene long non-coding RNA:CR44496 Neighboring gene Mst33A Neighboring gene Accessory gland-specific peptide 33A Neighboring gene sperm-associated antigen 4 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila kekkon genes: novel members of both the leucine-rich repeat and immunoglobulin superfamilies expressed in the CNS. Musacchio M, et al. Dev Biol, 1996 Aug 25. PMID 8812109
    2. Chronic exposure to titanium dioxide nanoparticles induces deficits of locomotor behavior by disrupting the development of NMJ in Drosophila. Zhang X, et al. Sci Total Environ, 2023 Aug 25. PMID 37196938
    3. Conservation of an inhibitor of the epidermal growth factor receptor, Kekkon1, in dipterans. Derheimer FA, et al. Genetics, 2004 Jan. PMID 15020419, Free PMC Article
    4. Comparative analysis of the Kekkon molecules, related members of the LIG superfamily. MacLaren CM, et al. Dev Genes Evol, 2004 Jul. PMID 15179511
    5. Bipartite inhibition of Drosophila epidermal growth factor receptor by the extracellular and transmembrane domains of Kekkon1. Alvarado D, et al. Genetics, 2004 May. PMID 15166146, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kekkon 2
    Names
    CG4977-PA
    Kekkon-2
    kek2-PA
    kekkon

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      11581937..11626883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_078827.3 → NP_523551.1  kekkon 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523551.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D1Z375, P91644, Q9VKG1
      Related
      FBpp0079836
      Conserved Domains (6) summary
      cd00116
      Location:80 → 187
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam07679
      Location:258 → 361
      I-set; Immunoglobulin I-set domain
      sd00033
      Location:34 → 52
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:79 → 138
      LRR_8; Leucine rich repeat
      pfam13895
      Location:263 → 361
      Ig_2; Immunoglobulin domain
      cl15307
      Location:207 → 256
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91644 P91644
    Q2XY26 Q2XY26
    Q9VKG1 Q9VKG1

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