Septin1 Septin 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Septin1provided by FlyBase
Official Full Name: Septin 1provided by FlyBase
Primary source: FLYBASE:FBgn0011710
Locus tag: Dmel_CG1403
See related: AllianceGenome:FB:FBgn0011710
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 38960; anon-19Fa; CG1403; Diff6; Dmel\CG1403; DSep1; dSEPT1; iby; sep1; Sep1; tu1
Summary: Enables several functions, including GTP binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Involved in imaginal disc-derived wing morphogenesis and positive regulation of apoptotic process. Located in cleavage furrow. Part of septin complex. Colocalizes with contractile ring. Is expressed in several structures, including adult head; brain; embryonic dorsal epidermis; embryonic ventral epidermis; and larval nervous system. Orthologous to human SEPTIN2 (septin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (21358286..21361688)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (21229313..21232715)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Septins regulate border cell surface geometry, shape, and motility downstream of Rho in Drosophila.
Title: Septins regulate border cell surface geometry, shape, and motility downstream of Rho in Drosophila.
Phosphorylation of Pnut in the early stages of Drosophila embryo development affects association of the Sep1-Sep2 complex with the membrane and is important for viability.
Title: Phosphorylation of Pnut in the Early Stages of Drosophila Embryo Development Affects Association of the Septin Complex with the Membrane and Is Important for Viability.
Sep1 is ubiquinated by Parkin and has a role in the neural cell death of autosomal recessive juvenile parkinsonism.
Title: Drosophila melanogaster Parkin ubiquitinates peanut and septin1 as an E3 ubiquitin-protein ligase.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellularization	TAS Traceable Author Statement more info	PubMed
involved_in cytoskeleton-dependent cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with contractile ring	HDA more info	PubMed
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
part_of septin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of septin complex	IDA Inferred from Direct Assay more info	PubMed
part_of septin complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in septin ring	IBA Inferred from Biological aspect of Ancestor more info