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    Klp98A Kinesin-like protein at 98A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43310, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klp98Aprovided by FlyBase
    Official Full Name
    Kinesin-like protein at 98Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004387
    Locus tag
    Dmel_CG5658
    See related
    AllianceGenome:FB:FBgn0004387
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5658; Dmel\CG5658; DmKlp98A; DmSNX23; KIF 16A; KIF16A/B; Klp6; KLP6; klp98A; Klp98a; KLP98A; Snx23
    Summary
    Enables phosphatidylinositol-3-phosphate binding activity and plus-end-directed microtubule motor activity. Involved in asymmetric protein localization involved in cell fate determination; plus-end-directed endosome transport along mitotic spindle midzone microtubule; and transcytosis. Colocalizes with early endosome. Orthologous to human KIF16B (kinesin family member 16B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Klp98A in Genome Data Viewer
    Location:
    98A4-98A6; 3-94 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (27547775..27559145, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (23373497..23384867, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 98c Neighboring gene Gustatory receptor 98d Neighboring gene small non-coding RNA 157 Neighboring gene uncharacterized protein Neighboring gene widerborst

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinesin and dynein move a peroxisome in vivo: a tug-of-war or coordinated movement? Kural C, et al. Science, 2005 Jun 3. PMID 15817813
    2. polo Is Identified as a Suppressor of bubR1 Nondisjunction in a Deficiency Screen of the Third Chromosome in Drosophila melanogaster. Sousa-Guimarães S, et al. G3 (Bethesda), 2011 Jul. PMID 22384328, Free PMC Article
    3. Identification and partial characterization of six members of the kinesin superfamily in Drosophila. Stewart RJ, et al. Proc Natl Acad Sci U S A, 1991 Oct 1. PMID 1924306, Free PMC Article
    4. An inverse PCR screen for the detection of P element insertions in cloned genomic intervals in Drosophila melanogaster. Dalby B, et al. Genetics, 1995 Feb. PMID 7713430, Free PMC Article
    5. With apologies to scheherazade: tails of 1001 kinesin motors. Goldstein LS. Annu Rev Genet, 1993. PMID 8122906

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The kinesin motor Klp98A mediates apical to basal Wg transport.
      Title: The kinesin motor Klp98A mediates apical to basal Wg transport.
    2. Klp98A-mediated fusion required the endolysosomal GTPase Rab14, which interacted and colocalized with Klp98A, and required Klp98A for normal localization.
      Title: Coordination of autophagosome-lysosome fusion and transport by a Klp98A-Rab14 complex in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plus-end-directed microtubule motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in asymmetric protein localization involved in cell fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in early endosome to late endosome transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in plus-end-directed endosome transport along mitotic spindle midzone microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle transport along microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with early endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Kinesin-like protein at 98A
    Names
    CG5658-PA
    CG5658-PB
    Kinesin7B
    Klp98A-PA
    Klp98A-PB
    NP_001247339.1
    NP_524532.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      27547775..27559145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260410.2 → NP_001247339.1  Kinesin-like protein at 98A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247339.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VB25
      Conserved Domains (6) summary
      cd06874
      Location:1090 → 1218
      PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
      smart00129
      Location:3 → 371
      KISc; Kinesin motor, catalytic domain. ATPase
      COG5134
      Location:606 → 768
      COG5134; Uncharacterized conserved protein [Function unknown]
      cd00060
      Location:456 → 555
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:2 → 371
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:370 → 478
      Kinesin_assoc; Kinesin-associated

    2. NM_079808.4 → NP_524532.2  Kinesin-like protein at 98A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524532.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4K7N6, Q00088, Q8SZH6, Q9VB25
      Related
      FBpp0084581
      Conserved Domains (5) summary
      cd06874
      Location:1131 → 1259
      PX_KIF16B_SNX23; The phosphoinositide binding Phox Homology domain of KIF16B kinesin or Sorting Nexin 23
      smart00129
      Location:3 → 371
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:456 → 555
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01365
      Location:2 → 371
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam16183
      Location:370 → 478
      Kinesin_assoc; Kinesin-associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VB25.2 Q9VB25

    Gene LinkOut

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