rdgC retinal degeneration C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: rdgCprovided by FlyBase
Official Full Name: retinal degeneration Cprovided by FlyBase
Primary source: FLYBASE:FBgn0265959
Locus tag: Dmel_CG44746
See related: AllianceGenome:FB:FBgn0265959
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG13814; CG44746; CG6571; Dmel\CG44746; DmrdgC-77B; RdgC; RDGC; RdgC 77B; RDGC/PP5
Old locus tag: Dmel_CG13814; Dmel_CG6571
Summary: Enables calcium-dependent protein serine/threonine phosphatase activity and calmodulin binding activity. Involved in negative regulation of opsin-mediated signaling pathway; phototransduction; and thermotaxis. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in Bolwig organ; adult head; eye; ocellus; and retina. Orthologous to human PPEF1 (protein phosphatase with EF-hand domain 1) and PPEF2 (protein phosphatase with EF-hand domain 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 77A4-77B1; 3-47 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (20248080..20265554)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (20241180..20258654)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification of a third RDGC protein variant, shows that the three RDGC isoforms harbor different N-termini that determine solubility and subcellular targeting due to fatty acylation. Taken together, solubility and subcellular targeting of RDGC splice variants are determined by their N-termini.
Title: Solubility and subcellular localization of the three Drosophila RDGC phosphatase variants are determined by acylation.
aken together, in vivo activities of RDGC splice variants are controlled by their N-termini.
Title: Functional characterization of the three Drosophila retinal degeneration C (RDGC) protein phosphatase isoforms.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 20257385-20258451 mobile_element_type = transposon:pogo{}1061
Loc: 20259544-20259622 mobile_element_type = transposon:INE-1{}5298

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	TAS Traceable Author Statement more info	PubMed
involved_in detection of stimulus involved in sensory perception	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of opsin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	TAS Traceable Author Statement more info	PubMed
involved_in thermotaxis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: retinal degeneration C

Names: CG44746-PB; CG44746-PF; CG44746-PG; CG44746-PH; CG44746-PI; rdgC-PB; rdgC-PF; rdgC-PG; rdgC-PH; rdgC-PI

NP_001356983.1

EC 3.-.-.-

EC 3.1.3.16

NP_536738.3

EC 3.-.-.-

EC 3.1.3.16

NP_788544.2

EC 3.-.-.-

EC 3.1.3.16

NP_788545.3

EC 3.-.-.-

EC 3.1.3.16

NP_788546.1

EC 3.-.-.-

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

20248080..20265554

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_176367.3 → NP_788545.3 retinal degeneration C, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788545.3

Status: REVIEWED

UniProtKB/Swiss-Prot

P40421

Conserved Domains (3) summary

smart00015
Location:89 → 111

IQ; Calmodulin-binding motif

cd00051
Location:616 → 681

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd07420
Location:184 → 494

MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
NM_176366.2 → NP_788544.2 retinal degeneration C, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788544.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P40421

Conserved Domains (3) summary

smart00015
Location:89 → 111

IQ; Calmodulin-binding motif

cd00051
Location:616 → 681

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd07420
Location:184 → 494

MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
NM_080490.4 → NP_536738.3 retinal degeneration C, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_536738.3

Status: REVIEWED

UniProtKB/Swiss-Prot

P40421

Conserved Domains (3) summary

smart00015
Location:89 → 111

IQ; Calmodulin-binding motif

cd00051
Location:616 → 681

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd07420
Location:184 → 494

MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
NM_176368.2 → NP_788546.1 retinal degeneration C, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_788546.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V255, P40421, Q5U1D3, Q9VWA4

Related

FBpp0309720

Conserved Domains (3) summary

smart00015
Location:7 → 26

IQ; Calmodulin-binding motif

cd00051
Location:531 → 596

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl13995
Location:99 → 409

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
NM_001370029.1 → NP_001356983.1 retinal degeneration C, isoform I [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4D6K426

Conserved Domains (3) summary

smart00015
Location:23 → 42

IQ; Calmodulin-binding motif

cd00051
Location:547 → 612

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cl13995
Location:115 → 425

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain