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    pb proboscipedia [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40826, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pbprovided by FlyBase
    Official Full Name
    proboscipediaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051481
    Locus tag
    Dmel_CG31481
    See related
    AllianceGenome:FB:FBgn0051481
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BG:DS01719.1; CG17880; CG31481; Dmel\CG31481; Dmpb; l(3)04498; Pb; PB; pd; pr
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in proboscis development; specification of segmental identity, labial segment; and specification of segmental identity, maxillary segment. Located in nucleus. Is expressed in several structures, including anterior ectoderm; embryonic segment; embryonic/larval foregut; ganglia; and labial disc. Orthologous to human HOXA2 (homeobox A2) and HOXB2 (homeobox B2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    84A5-84A5; 3-48 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6707800..6742063, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2533522..2567785, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ccp84Ab Neighboring gene Ccp84Aa Neighboring gene zerknullt-related Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The mutant "proboscipedia" in Drosophila melanogaster - A case of hereditary homoösis. Bridges CB, et al. Wilhelm Roux Arch Entwickl Mech Org, 1933 Dec. PMID 28354344
    2. Point mutations within and outside the homeodomain identify sequences required for proboscipedia homeotic function in Drosophila. Benassayag C, et al. Genetics, 1997 Jul. PMID 9215898, Free PMC Article
    3. A homeodomain point mutation of the Drosophila proboscipedia protein provokes eye loss independently of homeotic function. Benassayag C, et al. Mech Dev, 1997 May. PMID 9203141
    4. Analysis of Drosophila proboscipedia mutant alleles. Tayyab I, et al. Genome, 2004 Jun. PMID 15190377
    5. The proboscipedia locus of the Antennapedia complex: a molecular and genetic analysis. Pultz MA, et al. Genes Dev, 1988 Jul. PMID 2850265

    See all (233) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We also found that a base-mismatch can enable Loqs-PB to tune miRNA length. We speculate that Loqs-PB tunes miRNA length by changing the conformation of base-mismatched nucleotides in the pre-miRNA stem to that of base-matched ones.
      Title: Dicer partner protein tunes the length of miRNAs using base-mismatch in the pre-miRNA stem.
    2. Study shows that the LASCY, DYTQL, NANGE motifs, and the C-terminal domain of SCR mediate suppression of induction of ectopic proboscis identity, which would explain why co-expression of PB and SCR is unable to induce ectopic proboscises.
      Title: Developmental competence and the induction of ectopic proboscises in Drosophila melanogaster.
    3. The direct functional antagonism between PB and EY (eyeless) proteins suggests a novel crosstalk mechanism integrating known selector functions in head morphogenesis.
      Title: Evidence for a direct functional antagonism of the selector genes proboscipedia and eyeless in Drosophila head development.
    4. phenotypic analysis of the pb nonsense or frameshift alleles suggests that the C-terminus is an important region required for maxillary palp and proboscis development
      Title: Analysis of Drosophila proboscipedia mutant alleles.
    5. Functions in primary steps of tissue patterning, and leads us to suggest the notion of a homeotic organizer.
      Title: Homeotic proboscipedia function modulates hedgehog-mediated organizer activity to pattern adult Drosophila mouthparts.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: c6739283-6737554 mobile_element_type = transposon:Doc{}1240

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proboscis development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in specification of segmental identity, labial segment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in specification of segmental identity, maxillary segment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proboscipedia
    Names
    CG31481-PA
    CG31481-PB
    CG31481-PC
    CG31481-PD
    pb-PA
    pb-PB
    pb-PC
    pb-PD
    proboscopedia
    proposcipedia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6707800..6742063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206439.2 → NP_996161.1  proboscipedia, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996161.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P31264
      Conserved Domains (1) summary
      pfam00046
      Location:192 → 244
      Homeobox; Homeobox domain

    2. NM_206440.2 → NP_996162.1  proboscipedia, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996162.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P31264
      Conserved Domains (1) summary
      pfam00046
      Location:197 → 249
      Homeobox; Homeobox domain

    3. NM_206441.2 → NP_996163.1  proboscipedia, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996163.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P31264
      Conserved Domains (1) summary
      pfam00046
      Location:197 → 249
      Homeobox; Homeobox domain

    4. NM_057321.5 → NP_476669.3  proboscipedia, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476669.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O97058, P31264, Q4JFI5, Q9VI44
      Related
      FBpp0088333
      Conserved Domains (1) summary
      pfam00046
      Location:202 → 255
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31264.2 P31264

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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