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    CG11700 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31564, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11700provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029856
    Locus tag
    Dmel_CG11700
    See related
    AllianceGenome:FB:FBgn0029856
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-sts41; CR11700; Dmel\CG11700; ESTS:143G11T; ESTS:199A6T; poly-ub; Ub; Ubi-p5E5; Ubiquitin
    Summary
    Predicted to enable protein tag activity and ubiquitin protein ligase binding activity. Predicted to be a structural constituent of ribosome. Involved in determination of adult lifespan and negative regulation of reproductive process. Predicted to be active in cytoplasm and nucleus. Is expressed in organism; polar primary spermatocyte; and testis. Orthologous to human UBB (ubiquitin B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11700 in Genome Data Viewer
    Location:
    5E5-5E5; 1-16 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6282037..6283575, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6176070..6177608, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45530 Neighboring gene pseudo Neighboring gene Topoisomerase 3beta Neighboring gene wuho Neighboring gene Regulatory particle triple-A ATPase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease. Lee FK, et al. J Neurochem, 2009 Jul. PMID 19457126
    2. The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL. Miles JA, et al. J Biol Chem, 2015 Aug 21. PMID 26149689, Free PMC Article
    3. Rapid functional divergence of a newly evolved polyubiquitin gene in Drosophila and its role in the trade-off between male fecundity and lifespan. Zhan Z, et al. Mol Biol Evol, 2012 May. PMID 22135190
    4. Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism. Warrick JM, et al. Mol Cell, 2005 Apr 1. PMID 15808507
    5. An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways. Kamber Kaya HE, et al. PLoS Genet, 2017 Feb. PMID 28207763, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tag activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in modification-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11700-PB
    ubiquitin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6282037..6283575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132078.2 → NP_572306.1  uncharacterized protein Dmel_CG11700 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572306.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MT02, R9PY16
      Related
      FBpp0305700
      Conserved Domains (3) summary
      cd01803
      Location:153 → 228
      Ubiquitin; Ubiquitin
      smart00213
      Location:153 → 224
      UBQ; Ubiquitin homologues
      cl00155
      Location:229 → 296
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    R9PY16 R9PY16

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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    Research Materials
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