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    Oatp58Dc Organic anion transporting polypeptide 58Dc [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37545, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Oatp58Dcprovided by FlyBase
    Official Full Name
    Organic anion transporting polypeptide 58Dcprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034716
    Locus tag
    Dmel_CG3380
    See related
    AllianceGenome:FB:FBgn0034716
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3380; Dmel\CG3380; EcI-3; OATP; oatp 58Dc; OATP58Dc
    Summary
    Predicted to enable sodium-independent organic anion transmembrane transporter activity. Involved in renal tubular secretion and response to toxic substance. Located in basolateral plasma membrane. Is expressed in adult brain; adult brain surface glial cell; adult head; amnioserosa; and yolk nucleus. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder; gastrointestinal stromal tumor; and primary hypertrophic osteoarthropathy. Orthologous to several human genes including SLCO1A2 (solute carrier organic anion transporter family member 1A2); SLCO1B1 (solute carrier organic anion transporter family member 1B1); and SLCO1B3 (solute carrier organic anion transporter family member 1B3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Oatp58Dc in Genome Data Viewer
    Location:
    58D2-58D2; 2-99 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (22223681..22228574, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (18111186..18116079, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Organic anion transporting polypeptide 58Da Neighboring gene Organic anion transporting polypeptide 58Db Neighboring gene long non-coding RNA:CR44755 Neighboring gene defective proventriculus

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oatp58Dc contributes to blood-brain barrier function by excluding organic anions from the Drosophila brain. Seabrooke S, et al. Am J Physiol Cell Physiol, 2013 Sep. PMID 23804204
    2. Genetic knockdown of a single organic anion transporter alters the expression of functionally related genes in Malpighian tubules of Drosophila melanogaster. Chahine S, et al. J Exp Biol, 2012 Aug 1. PMID 22786636
    3. Effects of genetic knock-down of organic anion transporter genes on secretion of fluorescent organic ions by Malpighian tubules of Drosophila melanogaster. Chahine S, et al. Arch Insect Biochem Physiol, 2012 Dec. PMID 22972675
    4. The GABA(A) receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila. Chung BY, et al. Curr Biol, 2009 Mar 10. PMID 19230663, Free PMC Article
    5. Essential functions of mosquito ecdysone importers in development and reproduction. Hun LV, et al. Proc Natl Acad Sci U S A, 2022 Jun 21. PMID 35696563, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables organic anion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in organic anion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in renal tubular secretion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    organic anion transporting polypeptide 58Dc
    Names
    CG3380-PA
    CG3380-PB
    CG3380-PC
    Oatp58Dc-PA
    Oatp58Dc-PB
    Oatp58Dc-PC
    organic anion transporting polypeptide

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      22223681..22228574 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103939.2 → NP_001097409.1  organic anion transporting polypeptide 58Dc, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097409.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961X2, Q9W269
      Conserved Domains (3) summary
      cd06174
      Location:114 → 518
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:537 → 590
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:112 → 731
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    2. NM_137815.3 → NP_611659.2  organic anion transporting polypeptide 58Dc, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611659.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961X2, Q9W269
      Related
      FBpp0071690
      Conserved Domains (3) summary
      cd06174
      Location:114 → 518
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:537 → 590
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:112 → 731
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    3. NM_001169780.2 → NP_001163251.1  organic anion transporting polypeptide 58Dc, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163251.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q961X2, Q9W269
      Conserved Domains (3) summary
      cd06174
      Location:114 → 518
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:537 → 590
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:112 → 731
      OATP; Organic Anion Transporter Polypeptide (OATP) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q961X2 Q961X2
    Q9W269 Q9W269

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