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    Pof Painting of fourth [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37947, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pofprovided by FlyBase
    Official Full Name
    Painting of fourthprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035047
    Locus tag
    Dmel_CG3691
    See related
    AllianceGenome:FB:FBgn0035047
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg3691; CG3691; Dmel\CG3691; pof; POF
    Summary
    Enables chromatin binding activity. Involved in positive regulation of gene expression. Located in autosome and polytene chromosome. Is expressed in adult head and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pof in Genome Data Viewer
    Location:
    60D13-60D13; 2-107 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24669397..24671577)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20556920..20559100)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Matrix metalloproteinase 1 Neighboring gene Sialyltransferase Neighboring gene Mid1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Buffering of segmental and chromosomal aneuploidies in Drosophila melanogaster. Stenberg P, et al. PLoS Genet, 2009 May. PMID 19412336, Free PMC Article
    2. Painting of fourth, a chromosome-specific protein in Drosophila. Larsson J, et al. Proc Natl Acad Sci U S A, 2001 May 22. PMID 11353870, Free PMC Article
    3. Genome-wide mapping of Painting of fourth on Drosophila melanogaster salivary gland polytene chromosomes. Johansson AM, et al. Genom Data, 2014 Dec. PMID 26484072, Free PMC Article
    4. Epigenetic regulation of the Drosophila chromosome 4 by the histone H3K9 methyltransferase dSETDB1. Tzeng TY, et al. Proc Natl Acad Sci U S A, 2007 Jul 31. PMID 17652514, Free PMC Article
    5. POF regulates the expression of genes on the fourth chromosome in Drosophila melanogaster by binding to nascent RNA. Johansson AM, et al. Mol Cell Biol, 2012 Jun. PMID 22473994, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Painting of Fourth and the X-Linked 1.688 Satellite in D. melanogaster is Involved in Chromosome-Wide Gene Regulation.
      Title: Painting of Fourth and the X-Linked 1.688 Satellite in D. melanogaster is Involved in Chromosome-Wide Gene Regulation.
    2. The targeting of protein Painting of fourth to PoX1(POF-on-X) and PoX2 is largely dependent on roX expression and identified a high-affinity target region that ectopically recruits POF.
      Title: Targeting of Painting of fourth to roX1 and roX2 proximal sites suggests evolutionary links between dosage compensation and the regulation of the fourth chromosome in Drosophila melanogaster.
    3. POF binds to nascent RNA, and this binding is associated with increased transcription output from chromosome 4
      Title: POF regulates the expression of genes on the fourth chromosome in Drosophila melanogaster by binding to nascent RNA.
    4. Together with Egg, Wde (Windei) localizes to euchromatin, is enriched on chromosome 4, and binds to the Painting of fourth (POF) protein.
      Title: Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development.
    5. These results suggest a balancing mechanism for the regulation of the fourth chromosome where POF and HP1 competitively bind at increasing levels with increased transcriptional activity.
      Title: POF and HP1 bind expressed exons, suggesting a balancing mechanism for gene regulation.
    6. POF is involved in a chromosome-specific regulatory function
      Title: Painting of fourth in genus Drosophila suggests autosome-specific gene regulation.
    7. There is a balancing mechanism involving POF and HP1 that provides a feedback system for fine-tuning expression status of genes on the 4th chromosome.
      Title: Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in autosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    painting of fourth
    Names
    CG3691-PA
    CG3691-PB
    CG3691-PC
    Pof-PA
    Pof-PB
    Pof-PC
    painting of fourth chromosome
    painting on the fourth
    painting-of-fourth

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24669397..24671577
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079127.3 → NP_523851.1  painting of fourth, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523851.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8W2, Q9W123
      UniProtKB/TrEMBL
      A0A0B4K883
      Related
      FBpp0072234
      Conserved Domains (2) summary
      COG0724
      Location:201 → 292
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00590
      Location:217 → 285
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_166682.3 → NP_726472.1  painting of fourth, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726472.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8W2, Q9W123
      UniProtKB/TrEMBL
      A0A0B4K883
      Related
      FBpp0072235
      Conserved Domains (2) summary
      COG0724
      Location:201 → 292
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00590
      Location:217 → 285
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001259569.2 → NP_001246498.1  painting of fourth, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246498.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E8W2, Q9W123
      UniProtKB/TrEMBL
      A0A0B4K883
      Conserved Domains (2) summary
      COG0724
      Location:201 → 292
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd00590
      Location:217 → 285
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K883 A0A0B4K883
    Q9W123.1 Q9W123

    Gene LinkOut

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