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    Dhpr Dihydropteridine reductase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39050, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Dhprprovided by FlyBase
    Official Full Name
    Dihydropteridine reductaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035964
    Locus tag
    Dmel_CG4665
    See related
    AllianceGenome:FB:FBgn0035964
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4665; DHPR; Dmel\CG4665
    Summary
    Predicted to enable 6,7-dihydropteridine reductase activity; NADH binding activity; and NADPH binding activity. Predicted to be involved in L-phenylalanine catabolic process and tetrahydrobiopterin biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; adult heart; embryonic/larval midgut; embryonic/larval midgut primordium; and somatic trunk mesoderm derivative. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia C and phenylketonuria. Orthologous to human QDPR (quinoid dihydropteridine reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Dhpr in Genome Data Viewer
    Location:
    67A1-67A1; 3-28 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9134560..9135916)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9127660..9129016)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene boule Neighboring gene Unconventional SNARE in the ER 1 Neighboring gene nervous wreck Neighboring gene mir-4940 stem loop Neighboring gene Resistant to dieldrin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of Drosophila melanogaster dihydropteridine reductase. Park D, et al. Biochim Biophys Acta, 2000 Jun 21. PMID 11004497
    2. Comparison of inter- and intraspecies variation in humans and fruit flies. Shih J, et al. Genom Data, 2015 Mar. PMID 26484147, Free PMC Article
    3. graal: a Drosophila gene coding for several mosaic serine proteases. Munier AI, et al. Insect Biochem Mol Biol, 2004 Oct. PMID 15475297
    4. Retrotransposon-gene associations are widespread among D. melanogaster populations. Franchini LF, et al. Mol Biol Evol, 2004 Jul. PMID 15014149
    5. Studies on the glutathione S-transferase proteome of adult Drosophila melanogaster: responsiveness to chemical challenge. Alias Z, et al. Proteomics, 2007 Oct. PMID 17907271

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dhpr regulates mitochondrial morphology and tissue homeostasis by modulating S-nitrosylation of Drp1.
      Title: Large-scale RNAi screen identified Dhpr as a regulator of mitochondrial morphology and tissue homeostasis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 6,7-dihydropteridine reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADH binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADPH binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tetrahydrobiopterin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dihydropteridine reductase
    Names
    CG4665-PA
    CG4665-PB
    CG4665-PC
    Dhpr-PA
    Dhpr-PB
    Dhpr-PC
    NP_001014579.1
    NP_001014580.1
    NP_523990.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9134560..9135916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079266.5 → NP_523990.1  dihydropteridine reductase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523990.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSU6
      Related
      FBpp0076258
      Conserved Domains (2) summary
      cd05334
      Location:3 → 224
      DHPR_SDR_c_like; dihydropteridine reductase (DHPR), classical (c) SDRs
      pfam00106
      Location:6 → 188
      adh_short; short chain dehydrogenase

    2. NM_001014580.3 → NP_001014580.1  dihydropteridine reductase, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSU6
      Conserved Domains (2) summary
      cd05334
      Location:3 → 224
      DHPR_SDR_c_like; dihydropteridine reductase (DHPR), classical (c) SDRs
      pfam00106
      Location:6 → 188
      adh_short; short chain dehydrogenase

    3. NM_001014579.2 → NP_001014579.1  dihydropteridine reductase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014579.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VSU6
      Conserved Domains (2) summary
      cd05334
      Location:3 → 224
      DHPR_SDR_c_like; dihydropteridine reductase (DHPR), classical (c) SDRs
      pfam00106
      Location:6 → 188
      adh_short; short chain dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VSU6 Q9VSU6

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