bmm brummer [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: bmmprovided by FlyBase
Official Full Name: brummerprovided by FlyBase
Primary source: FLYBASE:FBgn0036449
Locus tag: Dmel_CG5295
See related: AllianceGenome:FB:FBgn0036449
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Atgl; ATGL; Bmm; BMM; CG5295; DmATGL; Dmel\CG5295; SCAP; TGL
Summary: Enables triacylglycerol lipase activity. Involved in several processes, including lipophagy; negative regulation of sequestering of triglyceride; and triglyceride metabolic process. Located in cytosol. Is active in lipid droplet. Is expressed in several structures, including adult head; anlage in statu nascendi; central brain anlage in statu nascendi; fat body; and gut section. Used to study acquired metabolic disease and obesity. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 10; coronary artery disease; liver disease (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including PNPLA2 (patatin like phospholipase domain containing 2); PNPLA3 (patatin like phospholipase domain containing 3); and PNPLA5 (patatin like phospholipase domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 70F5-70F5; 3-42 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (14776496..14786412, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (14769596..14779512, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An RDH-Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase.
Title: An RDH-Plin2 axis modulates lipid droplet size by antagonizing Bmm lipase.
Study identified bmm as a Hh signaling target gene directly regulated by Ci transcription factor that mediates Hh response in adipose tissue.
Title: Hedgehog signaling promotes lipolysis in adipose tissue through directly regulating Bmm/ATGL lipase.
A role for bmm function in the somatic cells of the gonad and in neurons in the regulation of male-female differences in fat storage and breakdown and bmm is a link between the regulation of triglyceride homeostasis and biological sex.
Title: A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown.
important for chronic accumulation and acute mobilization of storage fat
Title: Dual lipolytic control of body fat storage and mobilization in Drosophila.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables triacylglycerol lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables triacylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of sequestering of triglyceride	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lipid storage	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride mobilization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: brummer

Names: CG5295-PA; CG5295-PB; DmATGL; adipocyte triglyceride lipase; adipose triglyceride lipase; bmm-PA; bmm-PB; brummer TAG lipase; brummer lipase

NP_001163445.1

EC 3.-.-.-

EC 3.1.1.3

NP_648723.1

EC 3.-.-.-

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

14776496..14786412 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169974.2 → NP_001163445.1 brummer, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163445.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JI03

Conserved Domains (1) summary

cd07218
Location:1 → 245

Pat_iPLA2; Calcium-independent phospholipase A2; Classified as Group IVA-1 PLA2
NM_140466.2 → NP_648723.1 brummer, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648723.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VUH7

Related

FBpp0075449

Conserved Domains (1) summary

cd07218
Location:1 → 245

Pat_iPLA2; Calcium-independent phospholipase A2; Classified as Group IVA-1 PLA2