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    Antp Antennapedia [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40835, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Antpprovided by FlyBase
    Official Full Name
    Antennapediaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0260642
    Locus tag
    Dmel_CG1028
    See related
    AllianceGenome:FB:FBgn0260642
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    3.4; Ant; ANT-C; ANT-P; ANTC; antp; AntP; ANTP; Antp P1; Antp P2; Antp1; AntP1; Aus; BG:DS07700.1; CG1028; DmAntp; DMANTPE1; Dmel\CG1028; DRO15DC96Z; Hu; l(3)84Ba; Ns; Scx
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including muscle cell fate specification; neuroblast development; and regionalization. Located in cytoplasm and nucleus. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic segment posterior compartment; imaginal disc; neuroblast NB5-6; and neuromere. Orthologous to several human genes including HOXA7 (homeobox A7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Antp in Genome Data Viewer
    Location:
    84A6-84B2; 3-48 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (6896253..6999228, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2721975..2824950, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45559 Neighboring gene long non-coding RNA:CR44932 Neighboring gene long non-coding RNA:CR43252 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45899 Neighboring gene long non-coding RNA:CR44933

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Antennapedia gene is required and expressed in parasegments 4 and 5 of the Drosophila embryo. Martinez-Arias A. EMBO J, 1986 Jan. PMID 16453662, Free PMC Article
    2. Highly specific, membrane-permeant peptide blockers of cGMP-dependent protein kinase Ialpha inhibit NO-induced cerebral dilation. Dostmann WR, et al. Proc Natl Acad Sci U S A, 2000 Dec 19. PMID 11121077, Free PMC Article
    3. Vesicle membrane interactions of penetratin analogues. Persson D, et al. Biochemistry, 2004 Aug 31. PMID 15323563
    4. A homoeotic mutation transforming leg to antenna in Drosophila. Struhl G. Nature, 1981 Aug 13. PMID 7254358
    5. Structure-activity relationship of truncated and substituted analogues of the intracellular delivery vector Penetratin. Fischer PM, et al. J Pept Res, 2000 Feb. PMID 10784032

    See all (914) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Novel Antennapedia and Ultrabithorax trimeric complexes with TBP and Exd regulate transcription.
      Title: Novel Antennapedia and Ultrabithorax trimeric complexes with TBP and Exd regulate transcription.
    2. Antennapedia: The complexity of a master developmental transcription factor.
      Title: Antennapedia: The complexity of a master developmental transcription factor.
    3. Trimeric complexes of Antp-TBP with TFIIEbeta or Exd modulate transcriptional activity.
      Title: Trimeric complexes of Antp-TBP with TFIIEβ or Exd modulate transcriptional activity.
    4. Hox dosage contributes to flight appendage morphology in Drosophila.
      Title: Hox dosage contributes to flight appendage morphology in Drosophila.
    5. interaction of Antp with TFIIEbeta is important for the functional specificity of Antennapedia, and amino acids 32 and 36 in Antp HD helix 2 are key for this interaction
      Title: Transcription factor TFIIEβ interacts with two exposed positions in helix 2 of the Antennapedia homeodomain to control homeotic function in Drosophila.
    6. The Scr promoter interacts with distinct elements in the ftz-Antp interval.
      Title: An Organizational Hub of Developmentally Regulated Chromatin Loops in the Drosophila Antennapedia Complex.
    7. High levels of Antp promote the identity of motoneurons that target the distal regions of the femur and tibia.
      Title: Dual role for Hox genes and Hox co-factors in conferring leg motoneuron survival and identity in Drosophila.
    8. Functional synthetic Antennapedia genes and the YPWM motif play dual roles in transcriptional activation and repression.
      Title: Functional synthetic Antennapedia genes and the dual roles of YPWM motif and linker size in transcriptional activation and repression.
    9. The function of Antennapedia in the leg is not to repress homothorax, as has been suggested, but to directly repress spineless and other antennal genes that would otherwise be activated within this ring.
      Title: Control of the spineless antennal enhancer: direct repression of antennal target genes by Antennapedia.
    10. N-tail of Antp also improves the binding affinity for DNA, with a major contribution by the released waters.
      Title: Disordered tails of homeodomains facilitate DNA recognition by providing a trade-off between folding and specific binding.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in anterior/posterior axis specification TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in anterior/posterior pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in lymph gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in midgut development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in muscle cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuroblast development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in specification of segmental identity, antennal segment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in specification of segmental identity, thorax IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in specification of segmental identity, thorax TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ventral cord development HMP PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    antennapedia
    Names
    Antp-PD
    Antp-PE
    Antp-PF
    Antp-PG
    Antp-PH
    Antp-PI
    Antp-PJ
    Antp-PK
    Antp-PL
    Antp-PM
    Antp-PN
    Antp-PO
    Aus
    CG1028-PD
    CG1028-PE
    CG1028-PF
    CG1028-PG
    CG1028-PH
    CG1028-PI
    CG1028-PJ
    CG1028-PK
    CG1028-PL
    CG1028-PM
    CG1028-PN
    CG1028-PO
    Dm-Antennapedia
    Sex comb extra
    Sex combs extra
    antenapedia
    antennapaedia
    antennapedia P1
    antennapedia P2
    atennapedia
    humeral
    nasobemia
    NP_996167.1
    • unusual splice
    NP_996168.1
    • unusual splice
    NP_996169.1
    • unusual splice
    NP_996170.1
    • unusual splice
    NP_996172.1
    • unusual splice
    NP_996175.1
    • unusual splice

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      6896253..6999228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206451.1 → NP_996173.1  antennapedia, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996173.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6W4V0, Q7KSY7
      Conserved Domains (2) summary
      TIGR01628
      Location:203 → 277
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam00046
      Location:284 → 337
      Homeobox; Homeobox domain

    2. NM_206450.1 → NP_996172.1  antennapedia, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996172.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6W4V0, Q7KSY6
      Conserved Domains (2) summary
      TIGR01628
      Location:203 → 277
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam00046
      Location:288 → 341
      Homeobox; Homeobox domain

    3. NM_206449.1 → NP_996171.1  antennapedia, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996171.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6W4V0, Q7KSY5
      Conserved Domains (2) summary
      pfam00046
      Location:297 → 350
      Homeobox; Homeobox domain
      cl41729
      Location:161 → 302
      KLF1_2_4_N; N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins

    4. NM_206453.1 → NP_996175.1  antennapedia, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996175.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P02833, Q95SZ6
      UniProtKB/TrEMBL
      A4V2I6, D6W4V0
      Conserved Domains (2) summary
      pfam00046
      Location:301 → 354
      Homeobox; Homeobox domain
      cl41729
      Location:161 → 306
      KLF1_2_4_N; N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins

    5. NM_001382007.1 → NP_001368996.1  antennapedia, isoform O [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6W4V0, Q7KSY6
      Conserved Domains (2) summary
      TIGR01628
      Location:203 → 277
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam00046
      Location:288 → 341
      Homeobox; Homeobox domain

    6. NM_206444.1 → NP_996166.1  antennapedia, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996166.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6W4V0, Q7KSY7
      Conserved Domains (2) summary
      TIGR01628
      Location:203 → 277
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam00046
      Location:284 → 337
      Homeobox; Homeobox domain

    7. NM_206447.1 → NP_996169.1  antennapedia, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996169.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6W4V0, Q7KSY6
      Conserved Domains (2) summary
      TIGR01628
      Location:203 → 277
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam00046
      Location:288 → 341
      Homeobox; Homeobox domain

    8. NM_206452.1 → NP_996174.1  antennapedia, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996174.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D6W4V0, Q7KSY5
      Conserved Domains (2) summary
      pfam00046
      Location:297 → 350
      Homeobox; Homeobox domain
      cl41729
      Location:161 → 302
      KLF1_2_4_N; N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins

    9. NM_206448.1 → NP_996170.1  antennapedia, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996170.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P02833, Q95SZ6
      UniProtKB/TrEMBL
      A4V2I6, D6W4V0
      Conserved Domains (2) summary
      pfam00046
      Location:301 → 354
      Homeobox; Homeobox domain
      cl41729
      Location:161 → 306
      KLF1_2_4_N; N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins

    10. NM_206446.1 → NP_996168.1  antennapedia, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996168.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P02833, Q95SZ6
      UniProtKB/TrEMBL
      A4V2I6, D6W4V0
      Conserved Domains (2) summary
      pfam00046
      Location:301 → 354
      Homeobox; Homeobox domain
      cl41729
      Location:161 → 306
      KLF1_2_4_N; N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins

    11. NM_206445.1 → NP_996167.1  antennapedia, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996167.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P02833, Q95SZ6
      UniProtKB/TrEMBL
      A4V2I6, D6W4V0
      Conserved Domains (2) summary
      pfam00046
      Location:301 → 354
      Homeobox; Homeobox domain
      cl41729
      Location:161 → 306
      KLF1_2_4_N; N-terminal domain of Kruppel-like factor (KLF) 1, KLF2, KLF4, and similar proteins

    12. NM_206454.1 → NP_996176.1  antennapedia, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996176.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P02833
      Conserved Domains (1) summary
      TIGR01628
      Location:230 → 285
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V2I6 A4V2I6
    P02833.1 P02833
    Q7KSY5 Q7KSY5
    Q7KSY6 Q7KSY6
    Q7KSY7 Q7KSY7

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