Itpr Inositol 1,4,5,-trisphosphate receptor [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Itprprovided by FlyBase
Official Full Name: Inositol 1,4,5,-trisphosphate receptorprovided by FlyBase
Primary source: FLYBASE:FBgn0010051
Locus tag: Dmel_CG1063
See related: AllianceGenome:FB:FBgn0010051
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO02059370.49; CG1063; dip; DIP; dIP3R; dIP[[3]]R; Dmel\CG1063; DmInsP[[3R]]; DmInsP[[3]]R; Ins3PR; InsP(3); InsP3; Insp3R; InsP3R; InsP[[3]]; InsP[[3]]R; IP; ip3r; Ip3r; Ip3R; IP3R; IP[[3]] receptor; IP[[3]]R; Itp-r; Itp-r-83A; Itp-r42B; Itp-r83A; Itp-R83a; Itp-R83A; ITP-r83A; Itp-r[1]; itpr; ItpR; ITPR; itpr-83; ITPR1; l(3)05616; l(3)itpr; l(3)j5B4
Summary: Enables inositol 1,4,5-trisphosphate-gated calcium channel activity. Involved in several processes, including autophagic cell death; cellular response to ethanol; and fatty acid homeostasis. Located in axonal growth cone and smooth endoplasmic reticulum. Is expressed in several structures, including imaginal disc; mesoderm; organism subdivision; sense organ; and somatic muscle cell. Used to study autosomal dominant cerebellar ataxia and obesity. Human ortholog(s) of this gene implicated in several diseases, including Gillespie syndrome; amyotrophic lateral sclerosis; autosomal dominant cerebellar ataxia (multiple); isolated anhidrosis with normal sweat glands; and type 1 diabetes mellitus. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); ITPR2 (inositol 1,4,5-trisphosphate receptor type 2); and ITPR3 (inositol 1,4,5-trisphosphate receptor type 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 83A7-83B1; 3-47.5 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (5517117..5539411)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (1342839..1365133)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IP3-mediated Ca2+ signals regulate larval to pupal transition under nutrient stress through the H3K36 methyltransferase Set2.
Title: IP3-mediated Ca2+ signals regulate larval to pupal transition under nutrient stress through the H3K36 methyltransferase Set2.
Modulation of flight and feeding behaviours requires presynaptic IP3Rs in dopaminergic neurons.
Title: Modulation of flight and feeding behaviours requires presynaptic IP(3)Rs in dopaminergic neurons.
slow imaginal disc intercellular calcium waves (SIDICs) are mediated by the inositol-3-phosphate receptor, the endoplasmic reticulum (ER) calcium pump SERCA and the key gap junction component Inx2.
Title: Drosophila wing imaginal discs respond to mechanical injury via slow InsP3R-mediated intercellular calcium waves.
Study found that phototransduction was quantitatively unaffected not only after IP3R-RNAi, but also in IP3R-null mutants; describes novel phenotypes in photoreceptors from flies expressing the transcription factor (Gal4) used to drive RNAi expression. Results indicate that IP3R plays no significant role in Drosophila phototransduction while emphasizing the need for caution when using Gal4 drivers.
Title: Phototransduction in Drosophila Is Compromised by Gal4 Expression but not by InsP(3) Receptor Knockdown or Mutation.
cell-specific regulation of protein synthesis by IP3R in neuroendocrine cells influences protein metabolism.
Title: IP(3)R-mediated Ca(2+) release regulates protein metabolism in Drosophila neuroendocrine cells: implications for development under nutrient stress.
after depletion of Ca(2+) stores in Drosophila, translocation of the IP3R to Endoplasmic reticulum-plasma-membrane junctions facilitates the coupling of STIM to Orai that leads to activation of Store-operated Ca(2+) entry.
Title: Mutant IP3 receptors attenuate store-operated Ca2+ entry by destabilizing STIM-Orai interactions in Drosophila neurons.
The positive feedback between PLCbeta and IP3R found here may represent a common feature of the inositol-lipid signaling
Title: Functional cooperation between the IP3 receptor and phospholipase C secures the high sensitivity to light of Drosophila photoreceptors in vivo.
The present study shows that itpr function in peptidergic neurons is not only necessary but also sufficient for maintaining normal lipid metabolism in Drosophila.
Title: Loss of IP3 receptor function in neuropeptide secreting neurons leads to obesity in adult Drosophila.
InsP3R function alters lipid metabolism and causes hyperphagia.
Title: Altered lipid homeostasis in Drosophila InsP3 receptor mutants leads to obesity and hyperphagia.
Studies show that expression of transcripts related to carbohydrate and amine metabolism is altered in InsP(3) receptor mutant larvae.
Title: Patterns of gene expression in Drosophila InsP3 receptor mutant larvae reveal a role for InsP3 signaling in carbohydrate and energy metabolism.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 5518596-5518679 mobile_element_type = transposon:INE-1{}5230

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5 trisphosphate binding	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in autophagic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flight behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in molting cycle, chitin-based cuticle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear division	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in phototransduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ecdysteroid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of taste	IDA Inferred from Direct Assay more info	PubMed
involved_in stabilization of membrane potential	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in axonal growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in sarcoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in smooth endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inositol 1,4,5,-trisphosphate receptor

Names: 1, 4, 5-inositol trisphosphate receptor; CG1063-PA; CG1063-PB; CG1063-PC; IP3 receptor; IP[[3]] receptor; Inositol(1,4,5)-triphosphate receptor 42B; Ins(1,4,5)P[[3]] receptor; InsP[[3]] receptor; Itpr-PA; Itpr-PB; Itpr-PC; dm_IP3 receptor; inositol 1,4,5,-tris-phosphate receptor; inositol 1,4,5-triphosphate receptor; inositol 1,4,5-trisphosphate (InsP3) receptor; inositol 1,4,5-trisphosphate receptor; inositol triphosphate receptor 1; inositol trisphosphate receptor; inositol-1,3,5,-trisphosphate receptor; inositol-1,4,5-trisphosphate receptor; inositol-triphosphate receptor; ip3-receptor; type 1 InsP{3} receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

5517117..5539411

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300251.1 → NP_001287180.1 inositol 1,4,5,-trisphosphate receptor, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287180.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29993, Q24309, Q9U981, Q9VNC8

UniProtKB/TrEMBL

A0A0B4LGN1

Conserved Domains (7) summary

smart00472
Location:237 → 293

MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases

pfam00520
Location:2424 → 2682

Ion_trans; Ion transport protein

pfam01365
Location:495 → 691

RYDR_ITPR; RIH domain

pfam02815
Location:238 → 452

MIR; MIR domain

pfam06428
Location:2773 → 2810

Sec2p; GDP/GTP exchange factor Sec2p

pfam08454
Location:2033 → 2138

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:7 → 231

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_169060.2 → NP_730941.1 inositol 1,4,5,-trisphosphate receptor, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730941.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29993, Q24309, Q9U981, Q9VNC8

Related

FBpp0078336

Conserved Domains (7) summary

smart00472
Location:237 → 293

MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases

pfam00520
Location:2433 → 2691

Ion_trans; Ion transport protein

pfam01365
Location:495 → 691

RYDR_ITPR; RIH domain

pfam02815
Location:238 → 452

MIR; MIR domain

pfam06428
Location:2782 → 2819

Sec2p; GDP/GTP exchange factor Sec2p

pfam08454
Location:2042 → 2147

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:7 → 231

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_169061.2 → NP_730942.1 inositol 1,4,5,-trisphosphate receptor, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730942.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29993, Q24309, Q9U981, Q9VNC8

UniProtKB/TrEMBL

A0A0B4LGN1

Related

FBpp0078335

Conserved Domains (7) summary

smart00472
Location:237 → 293

MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases

pfam00520
Location:2424 → 2682

Ion_trans; Ion transport protein

pfam01365
Location:495 → 691

RYDR_ITPR; RIH domain

pfam02815
Location:238 → 452

MIR; MIR domain

pfam06428
Location:2773 → 2810

Sec2p; GDP/GTP exchange factor Sec2p

pfam08454
Location:2033 → 2138

RIH_assoc; RyR and IP3R Homology associated

pfam08709
Location:7 → 231

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor