YME1L YME1 like ATPase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: YME1Lprovided by FlyBase
Official Full Name: YME1 like ATPaseprovided by FlyBase
Primary source: FLYBASE:FBgn0034792
Locus tag: Dmel_CG3499
See related: AllianceGenome:FB:FBgn0034792
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3499; DmCG3499; Dmel\CG3499; dYME1L; dYME1L1
Summary: Predicted to enable ATP-dependent peptidase activity and metalloendopeptidase activity. Predicted to be involved in mitochondrial protein catabolic process and mitochondrial protein processing. Located in mitochondrion. Is expressed in several structures, including adult head; embryonic anal pad; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in optic atrophy 11. Orthologous to human YME1L1 (YME1 like 1 ATPase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 59B4-59B4; 2-101 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22882747..22886247, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18770270..18773770, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD.
Title: Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD.
CG3499 encodes the Drosophila homolog of the human i-AAA protease YME1L.
Title: Loss of Drosophila i-AAA protease, dYME1L, causes abnormal mitochondria and apoptotic degeneration.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent peptidase activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial protein processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of m-AAA complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: YME1 like ATPase

Names: CG3499-PB; CG3499-PC; CG3499-PD; YME1L-PB; YME1L-PC; YME1L-PD

NP_001246473.1

EC 3.4.24.-

NP_001261142.1

EC 3.4.24.-

NP_726263.1

EC 3.4.24.-

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

22882747..22886247 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001274213.2 → NP_001261142.1 YME1 like ATPase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261142.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KFY4

Conserved Domains (4) summary

TIGR01241
Location:254 → 735

FtsH_fam; ATP-dependent metalloprotease FtsH

pfam00004
Location:339 → 469

AAA; ATPase family associated with various cellular activities (AAA)

pfam01434
Location:549 → 733

Peptidase_M41; Peptidase family M41

cl21455
Location:302 → 358

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_166568.3 → NP_726263.1 YME1 like ATPase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726263.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9W1Y0

Related

FBpp0071817

Conserved Domains (4) summary

TIGR01241
Location:261 → 732

FtsH_fam; ATP-dependent metalloprotease FtsH

pfam00004
Location:336 → 466

AAA; ATPase family associated with various cellular activities (AAA)

pfam01434
Location:546 → 730

Peptidase_M41; Peptidase family M41

cl21455
Location:299 → 355

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_001259544.2 → NP_001246473.1 YME1 like ATPase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246473.1

Status: REVIEWED

UniProtKB/Swiss-Prot

F3YDF1, Q8MMD4, Q9W1Y0

Conserved Domains (1) summary

TIGR01241
Location:254 → 736

FtsH_fam; ATP-dependent metalloprotease FtsH