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    CG3630 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31189, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG3630provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0023540
    Locus tag
    Dmel_CG3630
    See related
    AllianceGenome:FB:FBgn0023540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    152A3.3; Dmel\CG3630; EG:152A3.3
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of transcription by RNA polymerase II. Predicted to be located in actin cytoskeleton. Predicted to be active in sarcomere. Is expressed in several structures, including adult head; embryonic central brain; embryonic foregut; embryonic foregut sensory structure; and embryonic hypopharynx. Orthologous to human ABRA (actin binding Rho activating protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG3630 in Genome Data Viewer
    Location:
    2D6-2D6; 1-0.6 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2162196..2172281)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2056229..2066314)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene wings apart-like Neighboring gene Cytochrome P450 4d1 Neighboring gene mir-3641 stem loop Neighboring gene antisense RNA:CR45479 Neighboring gene NADH dehydrogenase (ubiquinone) B14.5 A subunit Neighboring gene antisense RNA:CR44690 Neighboring gene Cytochrome P450 4d14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lmpt regulates the function of Drosophila muscle by acting as a repressor of Wnt signaling. Zhang J, et al. Gene, 2023 Aug 5. PMID 37245676
    2. Genetic and molecular analysis of wings apart-like (wapl), a gene controlling heterochromatin organization in Drosophila melanogaster. Vernì F, et al. Genetics, 2000 Apr. PMID 10747063, Free PMC Article
    3. Adipocyte Metabolic Pathways Regulated by Diet Control the Female Germline Stem Cell Lineage in Drosophila melanogaster. Matsuoka S, et al. Genetics, 2017 Jun. PMID 28396508, Free PMC Article
    4. Evidence for a selective sweep in the wapl region of Drosophila melanogaster. Beisswanger S, et al. Genetics, 2006 Jan. PMID 16204208, Free PMC Article
    5. MiR-980 Is a Memory Suppressor MicroRNA that Regulates the Autism-Susceptibility Gene A2bp1. Guven-Ozkan T, et al. Cell Rep, 2016 Feb 23. PMID 26876166, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in sarcomere IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG3630-PA
    CG3630-PB
    CG3630-PC
    CG3630-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2162196..2172281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272249.1 → NP_001259178.1  uncharacterized protein Dmel_CG3630, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259178.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46052
      Conserved Domains (1) summary
      pfam14705
      Location:79 → 155
      Costars; Costars

    2. NM_130627.4 → NP_569983.1  uncharacterized protein Dmel_CG3630, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_569983.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46052
      Related
      FBpp0070369
      Conserved Domains (1) summary
      pfam14705
      Location:79 → 155
      Costars; Costars

    3. NM_001272247.2 → NP_001259176.1  uncharacterized protein Dmel_CG3630, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259176.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDL0
      Conserved Domains (1) summary
      pfam14705
      Location:55 → 131
      Costars; Costars

    4. NM_001272248.2 → NP_001259177.1  uncharacterized protein Dmel_CG3630, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259177.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O46052
      Conserved Domains (1) summary
      pfam14705
      Location:79 → 155
      Costars; Costars
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDL0 M9PDL0
    O46052 O46052

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