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    bowl brother of odd with entrails limited [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33602, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bowlprovided by FlyBase
    Official Full Name
    brother of odd with entrails limitedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004893
    Locus tag
    Dmel_CG10021
    See related
    AllianceGenome:FB:FBgn0004893
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    17-29-5; Bowl; BOWL; CG10021; Dmel\CG10021; l(2)c; org2; Su(tor)2-1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in digestive tract morphogenesis; segmentation; and wing disc development. Predicted to be active in nucleus. Is expressed in several structures, including anlage in statu nascendi; cuboidal/columnar epithelium; embryonic/larval midgut primordium; gut section; and imaginal disc. Orthologous to human OSR2 (odd-skipped related transciption factor 2) and OSR1 (odd-skipped related transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bowl in Genome Data Viewer
    Location:
    24C3-24C4; 2-11 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3771700..3784121)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3771700..3784121)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43704 Neighboring gene mir-1004 stem loop Neighboring gene uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. lines and bowl affect the specification of cyst stem cells and niche cells in the Drosophila testis. Dinardo S, et al. Development, 2011 May. PMID 21486923, Free PMC Article
    2. Lin28 and Imp are Required for Stability of Bowl Transcripts in Hub Cells of the Drosophila Testis. To V, et al. Dev Reprod, 2021 Dec. PMID 35141457, Free PMC Article
    3. Comparison of the structure and expression of odd-skipped and two related genes that encode a new family of zinc finger proteins in Drosophila. Hart MC, et al. Genetics, 1996 Sep. PMID 8878683, Free PMC Article
    4. A shared ancient enhancer element differentially regulates the bric-a-brac tandem gene duplicates in the developing Drosophila leg. Bourbon HG, et al. PLoS Genet, 2022 Mar. PMID 35294439, Free PMC Article
    5. Tissue-specific enhancer repression through molecular integration of cell signaling inputs. Mojica-Vázquez LH, et al. PLoS Genet, 2017 Apr. PMID 28394894, Free PMC Article

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we find that C15 interacts physically with the Dll activator through contacts between their homeodomain and binds competitively with Dll to adjacent cognate sites on LAE, adding potential new layers of regulation by C15. Lastly, we show that C15 and Bowl activities regulate also rn expression
      Title: Tissue-specific enhancer repression through molecular integration of cell signaling inputs.
    2. Lines acts antagonistically to bowl in hub specification, establishing bowl as a positively acting factor in the development of the testis niche.
      Title: lines and bowl affect the specification of cyst stem cells and niche cells in the Drosophila testis.
    3. Together, lines and bowl act as a binary switch to generate a stable Notch signaling interface between Dl-expressing cells and adjacent distal cell.
      Title: Essential roles for lines in mediating leg and antennal proximodistal patterning and generating a stable Notch signaling interface at segment borders.
    4. Reciprocal roles are reported for bowl and lin in specifying the peripodial epithelium and the disc proper of the wing.
      Title: Reciprocal roles for bowl and lines in specifying the peripodial epithelium and the disc proper of the Drosophila wing primordium.
    5. Bowl is part of a genetic program that suppresses the formation of supernumerary appendages specifically in the fly's head.
      Title: An antennal-specific role for bowl in repressing supernumerary appendage development in Drosophila.
    6. Data shuw that Bowl protein, produced in response to Notch signaling, is required for the elaboration of pattern in the fruit fly tarsus.
      Title: Bowl is required downstream of Notch for elaboration of distal limb patterning.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in embryonic foregut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic hindgut morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic hindgut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic pattern specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in embryonic pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hindgut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived leg joint morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in terminal region determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    brother of odd with entrails limited
    Names
    CG10021-PA
    CG10021-PB
    CG10021-PC
    CG10021-PD
    CG10021-PF
    CG10021-PG
    CG10021-PH
    bowel
    bowl-PA
    bowl-PB
    bowl-PC
    bowl-PD
    bowl-PF
    bowl-PG
    bowl-PH
    odd skipped-related 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3771700..3784121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_164557.3 → NP_722940.1  brother of odd with entrails limited, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722940.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24219, Q9VQU9
      UniProtKB/TrEMBL
      A4V047
      Related
      FBpp0077179
      Conserved Domains (4) summary
      COG5048
      Location:232 → 372
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:240 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:322 → 344
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:252 → 277
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001258932.2 → NP_001245861.1  brother of odd with entrails limited, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245861.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24219, Q9VQU9
      UniProtKB/TrEMBL
      A4V047
      Conserved Domains (4) summary
      COG5048
      Location:232 → 372
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:240 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:322 → 344
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:252 → 277
      zf-H2C2_2; Zinc-finger double domain

    3. NM_057535.4 → NP_476883.1  brother of odd with entrails limited, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476883.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24219, Q9VQU9
      UniProtKB/TrEMBL
      A4V047
      Related
      FBpp0077180
      Conserved Domains (4) summary
      COG5048
      Location:232 → 372
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:240 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:322 → 344
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:252 → 277
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001258933.2 → NP_001245862.1  brother of odd with entrails limited, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245862.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24219, Q9VQU9
      UniProtKB/TrEMBL
      A4V047
      Conserved Domains (4) summary
      COG5048
      Location:232 → 372
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:240 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:322 → 344
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:252 → 277
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001258934.1 → NP_001245863.1  brother of odd with entrails limited, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245863.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24219, Q9VQU9
      UniProtKB/TrEMBL
      A4V047
      Conserved Domains (4) summary
      COG5048
      Location:232 → 372
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:240 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:322 → 344
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:252 → 277
      zf-H2C2_2; Zinc-finger double domain

    6. NM_164558.2 → NP_722941.1  brother of odd with entrails limited, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722941.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24219, Q9VQU9
      UniProtKB/TrEMBL
      A4V047
      Related
      FBpp0077181
      Conserved Domains (4) summary
      COG5048
      Location:232 → 372
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:240 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:322 → 344
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:252 → 277
      zf-H2C2_2; Zinc-finger double domain

    7. NM_164556.2 → NP_722939.1  brother of odd with entrails limited, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722939.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24219, Q9VQU9
      UniProtKB/TrEMBL
      A4V047
      Related
      FBpp0077182
      Conserved Domains (4) summary
      COG5048
      Location:232 → 372
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:240 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:322 → 344
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:252 → 277
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A4V047 A4V047
    Q9VQU9.1 Q9VQU9

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