mahj mahjong [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: mahjprovided by FlyBase
Official Full Name: mahjongprovided by FlyBase
Primary source: FLYBASE:FBgn0034641
Locus tag: Dmel_CG10080
See related: AllianceGenome:FB:FBgn0034641
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0172774.151; BcDNA:SD08722; CG10080; Dmel\CG10080; Mahj; VprBP
Summary: Involved in cell competition in a multicellular organism. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in nucleus. Is expressed in spermatozoon. Orthologous to human DCAF1 (DDB1 and CUL4 associated factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 57F4-57F5; 2-96 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (21625030..21631422)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (17512535..17518927)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data indicate that Mahjong interacts with Lgl biochemically and genetically and that Mahjong and Lgl function in the same pathway to regulate cellular competitiveness.[Mahjong]
Title: Involvement of Lgl and Mahjong/VprBP in cell competition.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell competition in a multicellular organism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: mahjong

Names: CG10080-PA; CG10080-PB; mahj-PA; mahj-PB

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

21625030..21631422

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001259522.2 → NP_001246451.1 mahjong, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246451.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5U167, Q86PE6, Q8MT13, Q9W2F2

UniProtKB/TrEMBL

A0A0B4K8A5

Conserved Domains (4) summary

smart00667
Location:912 → 944

LisH; Lissencephaly type-1-like homology motif

COG2319
Location:1194 → 1423

WD40; WD40 repeat [General function prediction only]

sd00039
Location:1159 → 1192

7WD40; WD40 repeat [structural motif]

cl02567
Location:1159 → 1350

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_137748.4 → NP_611592.2 mahjong, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611592.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5U167, Q86PE6, Q8MT13, Q9W2F2

UniProtKB/TrEMBL

A0A0B4K8A5

Related

FBpp0071575

Conserved Domains (4) summary

smart00667
Location:912 → 944

LisH; Lissencephaly type-1-like homology motif

COG2319
Location:1194 → 1423

WD40; WD40 repeat [General function prediction only]

sd00039
Location:1159 → 1192

7WD40; WD40 repeat [structural motif]

cl02567
Location:1159 → 1350

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...