trpl transient receptor potential-like [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: trplprovided by FlyBase
Official Full Name: transient receptor potential-likeprovided by FlyBase
Primary source: FLYBASE:FBgn0005614
Locus tag: Dmel_CG18345
See related: AllianceGenome:FB:FBgn0005614
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG1694; CG18345; Dmel\CG18345; DmTRPL; dTrpL; dTRPL; trp-l; TRP-Like; trpL; Trpl; TrpL; TRPL
Summary: Enables several functions, including calmodulin binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including cellular response to anoxia; phototransduction, visible light; and sensory perception of sound. Located in dendrite and rhabdomere microvillus membrane. Part of cation channel complex and inaD signaling complex. Is expressed in several structures, including adult gnathal ganglion; eye disc; organism subdivision; photoreceptor neurons; and sense organ. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to human TRPC4 (transient receptor potential cation channel subfamily C member 4) and TRPC5 (transient receptor potential cation channel subfamily C member 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 46B2-46B2; 2-61 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (9753697..9765518)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (5641202..5653023)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effect of experimental infection with P. aeruginosa on trpl expression in male Drosophila melanogaster flies from different genetic backgrounds exposed by pricking or by ingestion showed downregulation in the whole body and the intestines. The downregulation of trpl in gammaCop mutant males is not confirmed by qRT-PCR data.
Title: Effects of Pseudomonas aeruginosa infection on the expression profile of transient receptor potential-like (TRPL) gene from Drosophila melanogaster.
effects of cholesterol depletion on the TRPL channel activity
Title: Depletion of Membrane Cholesterol Suppresses Drosophila Transient Receptor Potential-Like (TRPL) Channel Activity.
CG17352 (CULD) plays an important role in the endocytic turnover of Rh1 and TRPL.
Title: CULD is required for rhodopsin and TRPL channel endocytic trafficking and survival of photoreceptor cells.
conclusion, TTD14 is a novel regulator of TRPL trafficking, involved in internalization and subsequent sorting of TRPL into the recycling pathway that enables this ion channel to return to the plasma membrane
Title: The GTP- and Phospholipid-Binding Protein TTD14 Regulates Trafficking of the TRPL Ion Channel in Drosophila Photoreceptor Cells.
The transient receptor potential-like (TRPL) cation channel is a direct target for camphor in gustatory receptor neurons; long-term feeding on a camphor diet leads to reversible downregulation of TRPL protein concentrations.
Title: Food experience-induced taste desensitization modulated by the Drosophila TRPL channel.
TRP and TRPL assemble exclusively as homomultimeric channels in their native environment.
Title: Drosophila TRP and TRPL are assembled as homomultimeric channels in vivo.
a light-dependent switch in the phosphorylation pattern of the TRPL channel mediates stable expression of TRPL in the rhabdomeres upon prolonged dark-adaptation.
Title: Mutation of light-dependent phosphorylation sites of the Drosophila transient receptor potential-like (TRPL) ion channel affects its subcellular localization and stability.
These observations show that reduction in TRPC channel function significantly reduces the sensitivity of the olfactory response to CO(2) concentrations of 5% or less in adult Drosophila
Title: Mutants in Drosophila TRPC channels reduce olfactory sensitivity to carbon dioxide.
Vesicle exocytosis depends on cacophony, TRP and TRPL.
Title: TRP, TRPL and cacophony channels mediate Ca2+ influx and exocytosis in photoreceptors axons in Drosophila.
TRPL channel is constitutively active in S2 cells but is silent in HEK cells.
Title: The activity of the TRP-like channel depends on its expression system.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium channel activity	IGI Inferred from Genetic Interaction more info	PubMed
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables calmodulin binding	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic cation channel activity	TAS Traceable Author Statement more info	PubMed
enables monoatomic ion transmembrane transporter activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables store-operated calcium channel activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in body fluid secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to anoxia	IGI Inferred from Genetic Interaction more info	PubMed
involved_in detection of light stimulus involved in visual perception	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in monoatomic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transport	NAS Non-traceable Author Statement more info	PubMed
involved_in phototransduction, visible light	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to light stimulus	TAS Traceable Author Statement more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cation channel complex	IPI Inferred from Physical Interaction more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
part_of inaD signaling complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in rhabdomere	IDA Inferred from Direct Assay more info	PubMed
located_in rhabdomere	TAS Traceable Author Statement more info	PubMed
located_in rhabdomere microvillus membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: transient receptor potential-like

Names: CG18345-PA; CG18345-PB; CG18345-PD; TRP-like; transient receptor Potential-Like; trpl-PA; trpl-PB; trpl-PD

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

9753697..9765518

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165694.3 → NP_724822.1 transient receptor potential-like, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724822.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C6TPC1, P48994, Q0E9E3, Q8IH62, Q8MKU9, Q9V5B2

Related

FBpp0087557

Conserved Domains (5) summary

cd00204
Location:48 → 195

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:48 → 784

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:187 → 246

TRP_2; Transient receptor ion channel II

sd00045
Location:78 → 114

ANK; ANK repeat [structural motif]

cl09810
Location:706 → 805

DUF2031; Protein of unknown function (DUF2031)
NM_057547.5 → NP_476895.1 transient receptor potential-like, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476895.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C6TPC1, P48994, Q0E9E3, Q8IH62, Q8MKU9, Q9V5B2

Related

FBpp0087555

Conserved Domains (5) summary

cd00204
Location:48 → 195

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:48 → 784

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:187 → 246

TRP_2; Transient receptor ion channel II

sd00045
Location:78 → 114

ANK; ANK repeat [structural motif]

cl09810
Location:706 → 805

DUF2031; Protein of unknown function (DUF2031)
NM_165695.2 → NP_724823.2 transient receptor potential-like, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724823.2

Status: REVIEWED

UniProtKB/Swiss-Prot

C6TPC1, P48994, Q0E9E3, Q8IH62, Q8MKU9, Q9V5B2

Conserved Domains (5) summary

cd00204
Location:48 → 195

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:48 → 784

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:187 → 246

TRP_2; Transient receptor ion channel II

sd00045
Location:78 → 114

ANK; ANK repeat [structural motif]

cl09810
Location:706 → 805

DUF2031; Protein of unknown function (DUF2031)