U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Nazo nazo [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40976, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Nazoprovided by FlyBase
    Official Full Name
    nazoprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037562
    Locus tag
    Dmel_CG11671
    See related
    AllianceGenome:FB:FBgn0037562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM23845; CG11671; Dmel\CG11671; nazo
    Summary
    Involved in defense response to virus and neuromuscular process. Is expressed in adult abdomen; adult head; and adult thorax. Used to study neurodegeneration with brain iron accumulation 4. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 43 and neurodegeneration with brain iron accumulation 4. Orthologous to human C19orf12 (chromosome 19 open reading frame 12). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Nazo in Genome Data Viewer
    Location:
    84F8-84F8; 3-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8287876..8288613)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4113598..4114335)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene atonal Neighboring gene long non-coding RNA:CR44318 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Impairment of Drosophila orthologs of the human orphan protein C19orf12 induces bang sensitivity and neurodegeneration. Iuso A, et al. PLoS One, 2014. PMID 24586779, Free PMC Article
    2. The genetic basis of variation in sexual aggression: Evolution versus social plasticity. Scott AM, et al. Mol Ecol, 2022 May. PMID 35313034
    3. Nazo, the Drosophila homolog of the NBIA-mutated protein-c19orf12, is required for triglyceride homeostasis. Sreejith P, et al. PLoS Genet, 2024 Feb. PMID 38335241, Free PMC Article
    4. Dietary Supplementation of Aspirin Promotes Drosophila Defense against Viral Infection. Kong F, et al. Molecules, 2023 Jul 9. PMID 37513173, Free PMC Article
    5. Drosophila melanogaster Sting mediates Coxiella burnetii infection by reducing accumulation of reactive oxygen species. Guzman RM, et al. Infect Immun, 2024 Mar 12. PMID 38363133, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuromuscular process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    nazo
    Names
    CG11671-PA
    Nazo-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8287876..8288613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141521.2 → NP_649778.1  nazo [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649778.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VHT9
      Related
      FBpp0081319
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VHT9.2 Q9VHT9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools