trsn translin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: trsnprovided by FlyBase
Official Full Name: translinprovided by FlyBase
Primary source: FLYBASE:FBgn0033528
Locus tag: Dmel_CG11761
See related: AllianceGenome:FB:FBgn0033528
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11761; Dmel\CG11761; TB-RBP
Summary: Enables protein homodimerization activity. Involved in several processes, including behavioral response to starvation; negative regulation of circadian sleep/wake cycle, sleep; and protein stabilization. Located in cytosol. Is expressed in several structures, including adult brain; embryonic/larval epidermis; embryonic/larval oenocyte; larval abdomen; and testis. Orthologous to human TSN (translin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 47A11-47A11; 2-62 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (10479011..10480111, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (6366516..6367616, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

it has been shown that translin is upregulated under starvation conditions in Drosophila and is involved in the integration of sleep and metabolic rate of the flies.
Title: Translin: A multifunctional protein involved in nucleic acid metabolism.
Findings indicate that the loss of Translin/TRAX complex (dmC3PO) promoted the accumulation of the passenger strand of esi-2.1 (hp-CG4068B) and increased the accumulation of miR-bantam.
Title: Opposite effects of Drosophila C3PO on gene silencing mediated by esi-2.1 and miRNA-bantam.
Study describes the identification of translin (trsn), a highly conserved RNA/DNA binding protein, as essential for starvation-induced sleep suppression. Strikingly, trsn does not appear to regulate energy stores, free glucose levels, or feeding behavior suggesting the sleep phenotype of trsn mutant flies is not a consequence of general metabolic dysfunction or blunted response to starvation.
Title: translin Is Required for Metabolic Regulation of Sleep.
These studies establish that Trax adopts the translin fold, possesses catalytic centers essential for C3PO's endoRNase activity and interacts extensively with translin to form an octameric assembly.
Title: Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex.
an RNAi regulator that we term C3PO (component 3 promoter of RISC), a complex of Translin and Trax was purified; C3PO is a Mg2+-dependent endoribonuclease that promotes RISC activation by removing siRNA passenger strand cleavage products
Title: C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation.
Results suggest that the oligomeric status of translin critically influences the DNA binding properties of translin proteins.
Title: Crystal structures of Drosophila mutant translin and characterization of translin variants reveal the structural plasticity of translin proteins.
Drosophila translin may have roles in neuronal development and behavior analogous to that of mouse translin.
Title: Expression pattern of Drosophila translin and behavioral analyses of the mutant.
Drosophila translin exhibits a stable dimeric state that assembles into a suboctameric (tetramer/hexamer) form and fails to bind ssDNA and RNA targets
Title: GTP-induced conformational changes in translin: a comparison between human and Drosophila proteins.
A translin null mutant was generated and a trax nonsense mutation was isolated. Translin is essential for stabilizing its interaction with trax.
Title: Functional characterization of Drosophila Translin and Trax.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
NOT enables RNA endonuclease activity	IKR Inferred from Key Residues more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in RNA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in behavioral response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein stabilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: translin

Names: CG11761-PA; testis-brain RNA binding protein; trsn-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

10479011..10480111 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_136747.4 → NP_610591.1 translin [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_610591.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JVK6

Related

FBpp0087398

Conserved Domains (1) summary

cd14819
Location:13 → 217

Translin; Translin, also known as TB-RBP (testis brain RNA-binding protein)