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    Coq9 Coenzyme Q9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 246650, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Coq9provided by FlyBase
    Official Full Name
    Coenzyme Q9provided by FlyBase
    Primary source
    FLYBASE:FBgn0050493
    Locus tag
    Dmel_CG30493
    See related
    AllianceGenome:FB:FBgn0050493
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1952; CG30493; Dmel\CG30493
    Summary
    Predicted to enable lipid binding activity. Predicted to be involved in ubiquinone biosynthetic process. Predicted to be part of ubiquinone biosynthesis complex. Predicted to be active in mitochondrial inner membrane. Is expressed in adult head and adult heart. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 5. Orthologous to human COQ9 (coenzyme Q9). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Coq9 in Genome Data Viewer
    Location:
    43E11-43E11; 2-57 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7699253..7703501)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3586758..3591006)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene U2A Neighboring gene Leucine-rich repeat Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene torso

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Personalized Model of COQ2 Nephropathy Rescued by the Wild-Type COQ2 Allele or Dietary Coenzyme Q(10) Supplementation. Zhu JY, et al. J Am Soc Nephrol, 2017 Sep. PMID 28428331, Free PMC Article
    2. Invertebrate models for coenzyme q10 deficiency. Fernández-Ayala DJ, et al. Mol Syndromol, 2014 Jul. PMID 25126050, Free PMC Article
    3. In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway. Lindström R, et al. BMC Genet, 2017 Jun 2. PMID 28578657, Free PMC Article
    4. Filtering of Data-Driven Gene Regulatory Networks Using Drosophila melanogaster as a Case Study. Cuesta-Astroz Y, et al. Front Genet, 2021. PMID 34394179, Free PMC Article
    5. A large-scale RNAi screen reveals that mitochondrial function is important for meiotic chromosome organization in oocytes. Nieken KJ, et al. Chromosoma, 2023 Mar. PMID 36648541, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ubiquinone biosynthesis complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    coenzyme Q9
    Names
    CG30493-PB
    Coq9-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7699253..7703501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165550.3 → NP_724594.1  coenzyme Q9 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724594.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MKN0, Q8T8R0
      UniProtKB/TrEMBL
      B5RJR6
      Related
      FBpp0087999
      Conserved Domains (2) summary
      TIGR02396
      Location:110 → 297
      diverge_rpsU; rpsU-divergently transcribed protein
      pfam08511
      Location:217 → 287
      COQ9; COQ9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MKN0.1 Q8MKN0

    Gene LinkOut

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