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    mtrm matrimony [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38958, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mtrmprovided by FlyBase
    Official Full Name
    matrimonyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010431
    Locus tag
    Dmel_CG18543
    See related
    AllianceGenome:FB:FBgn0010431
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-D52; anonD52; CG18543; D52; Dmel\CG18543; Mtrm
    Summary
    Involved in meiotic chromosome segregation and regulation of meiotic cell cycle. Located in nucleus. Is expressed in nurse cell; oocyte; organism; and ovary. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See mtrm in Genome Data Viewer
    Location:
    66C11-66C11; 3-24 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8413012..8414103)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8406112..8407203)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene monkey king protein Neighboring gene tRNA 2'-phosphotransferase Neighboring gene uncharacterized protein Neighboring gene Outer segment 1 Neighboring gene Exocyst 70 Neighboring gene uncharacterized protein Neighboring gene Cbl proto-oncogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. B chromosomes reveal a female meiotic drive suppression system in Drosophila melanogaster. Hanlon SL, et al. Curr Biol, 2023 Jun 5. PMID 37146608, Free PMC Article
    2. Matrimony ties Polo down: can this kinase get free? Smith SK, et al. Cell Cycle, 2008 Mar 15. PMID 18245949
    3. Binding of Drosophila Polo kinase to its regulator Matrimony is noncanonical and involves two separate functional domains. Bonner AM, et al. Proc Natl Acad Sci U S A, 2013 Mar 26. PMID 23479640, Free PMC Article
    4. Aging predisposes oocytes to meiotic nondisjunction when the cohesin subunit SMC1 is reduced. Subramanian VV, et al. PLoS Genet, 2008 Nov. PMID 19008956, Free PMC Article
    5. Functional Consequences of the Evolution of Matrimony, a Meiosis-Specific Inhibitor of Polo Kinase. Bonner AM, et al. Mol Biol Evol, 2019 Jan 1. PMID 30351378, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of Polo Kinase by Matrimony Is Required for Cohesin Maintenance during Drosophila melanogaster Female Meiosis.
      Title: Regulation of Polo Kinase by Matrimony Is Required for Cohesin Maintenance during Drosophila melanogaster Female Meiosis.
    2. We showed that Mtrm is subject to APC(Cort)-mediated proteasomal degradation and have identified a putative APC/C recognition motif in Mtrm that when mutated partially stabilized the protein in the embryo.
      Title: A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony.
    3. Binding of Drosophila Polo kinase to its regulator Matrimony is noncanonical and involves two separate functional domains.
      Title: Binding of Drosophila Polo kinase to its regulator Matrimony is noncanonical and involves two separate functional domains.
    4. In female meiosis, Mtrm regulates Polo's role in promoting nuclear envelope breakdown and the subsequent entry of the oocyte into prometaphase.
      Title: Matrimony ties Polo down: can this kinase get free?
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in distributive segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in female meiosis chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in homologous chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    matrimony
    Names
    CG18543-PA
    mtrm-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8413012..8414103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139966.3 → NP_648223.1  matrimony [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648223.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B6UX71, B6UX75, B6UX76, B6UX77, B6UX82, B6UX83, B6UX94, Q23973, Q9VSJ7
      Related
      FBpp0076340
      Conserved Domains (2) summary
      smart00454
      Location:154 → 217
      SAM; Sterile alpha motif
      cl15755
      Location:162 → 210
      SAM_superfamily; SAM (Sterile alpha motif )
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q23973.2 Q23973

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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