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    CG14507 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43461, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CG14507provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039655
    Locus tag
    Dmel_CG14507
    See related
    AllianceGenome:FB:FBgn0039655
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG14507
    Summary
    Predicted to enable calcium-dependent phospholipase A2 activity. Predicted to be involved in arachidonate secretion; lipid catabolic process; and phospholipid metabolic process. Human ortholog(s) of this gene implicated in cholecystolithiasis; colorectal cancer; familial benign fleck retina; gastroesophageal reflux disease; and human immunodeficiency virus infectious disease. Orthologous to several human genes including PLA2G2A (phospholipase A2 group IIA); PLA2G2D (phospholipase A2 group IID); and PLA2G2E (phospholipase A2 group IIE). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG14507 in Genome Data Viewer
    Location:
    99A1-99A1; 3-98 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29226204..29227725, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25051926..25053447, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 gamma Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene Bromodomain containing 8 Neighboring gene Ubiquitin specific protease 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gene induction following wounding of wild-type versus macrophage-deficient Drosophila embryos. Stramer B, et al. EMBO Rep, 2008 May. PMID 18344972, Free PMC Article
    2. Clotting factors and eicosanoids protect against nematode infections. Hyrsl P, et al. J Innate Immun, 2011. PMID 20948189
    3. Drosophila Fed ARA and EPA Yields Eicosanoids, 15S-Hydroxy-5Z,8Z, 11Z, 13E-Eicosatetraenoic Acid, and 15S-Hydroxy-5Z,8Z,11Z,13E,17Z-Eicosapentaenoic Acid. Tan L, et al. Lipids, 2016 Apr. PMID 26931457
    4. Drosophila spermatid individualization is sensitive to temperature and fatty acid metabolism. Ben-David G, et al. Spermatogenesis, 2015 Jan-Apr. PMID 26413411, Free PMC Article
    5. Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila. Qurashi A, et al. Hum Mol Genet, 2012 May 1. PMID 22298836, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent phospholipase A2 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phospholipase A2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14507-PC
    NP_001097964.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      29226204..29227725 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104494.2 → NP_001097964.1  uncharacterized protein Dmel_CG14507 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097964.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3DND2, Q8IML0
      Conserved Domains (1) summary
      cd00125
      Location:243 → 357
      PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IML0 Q8IML0

    Gene LinkOut

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