U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Zyx Zyxin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 317824, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Zyxprovided by FlyBase
    Official Full Name
    Zyxinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011642
    Locus tag
    Dmel_CG32018
    See related
    AllianceGenome:FB:FBgn0011642
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD06023; CG32018; DLim-1; Dmel\CG32018; DmLIM-1; lim; Lim102EF; zyx; ZYX; zyx102; Zyx102; ZYX102; Zyx102EF; zyxin
    Summary
    Involved in several processes, including imaginal disc-derived wing expansion; open tracheal system development; and positive regulation of developmental growth. Located in stress fiber. Part of subapical complex. Is expressed in organism; pole plasm; and primordial germ cell. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to several human genes including LPP (LIM domain containing preferred translocation partner in lipoma). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Zyx in Genome Data Viewer
    Location:
    102F7-102F8; 4-0 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (1057365..1065001, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (1077991..1085627, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene ATP synthase, beta subunit Neighboring gene uncharacterized protein Neighboring gene Calcium/calmodulin-dependent protein kinase II Neighboring gene apolipophorin Neighboring gene Activin-beta Neighboring gene shaven Neighboring gene Calsyntenin

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The cytoskeletal regulator zyxin is required for viability in Drosophila melanogaster. Renfranz PJ, et al. Anat Rec (Hoboken), 2010 Sep. PMID 20648572, Free PMC Article
    2. Mechanosensing in actin stress fibers revealed by a close correlation between force and protein localization. Colombelli J, et al. J Cell Sci, 2009 May 15. PMID 19401336
    3. Drosophila myosin-XX functions as an actin-binding protein to facilitate the interaction between Zyx102 and actin. Cao Y, et al. Biochemistry, 2014 Jan 21. PMID 24393048
    4. Drosophila integrin adhesion complexes are essential for hemocyte migration in vivo. Moreira CG, et al. Biol Open, 2013 Aug 15. PMID 23951405, Free PMC Article
    5. Molecular and phylogenetic characterization of Zyx102, a Drosophila orthologue of the zyxin family that interacts with Drosophila Enabled. Renfranz PJ, et al. Gene, 2003 Feb 13. PMID 12594038

    See all (64) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results show that Zyxin is a functional antagonist of Expanded in growth control
      Title: Zyxin antagonizes the FERM protein expanded to couple F-actin and Yorkie-dependent organ growth.
    2. The motor domain of DmMyo20 could specifically bind to actin filaments in an ATP-independent manner and enhance the interaction between actin filaments and Zyx102, a downstream component of DmMyo20 in the Fat signaling pathway.
      Title: Drosophila myosin-XX functions as an actin-binding protein to facilitate the interaction between Zyx102 and actin.
    3. Through epistasis tests, the requirement for Zyx is positioned within the Fat branch of Hippo signaling, downstream of Fat and Dco, and upstream of the Yorkie kinase Warts.
      Title: Zyxin links fat signaling to the hippo pathway.
    4. Reduction of Zyx102 protein levels using RNA-interference results in lethality at the pharate adult stage.
      Title: The cytoskeletal regulator zyxin is required for viability in Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    mobile_element

    • Loc: c1063824-1063604 mobile_element_type = transposon:S{}1551

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chitin-based cuticle sclerotization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing expansion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in liquid clearance, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of hippo signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of eclosion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of imaginal disc growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in terminal branching, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell-cell junction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in stress fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stress fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of subapical complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    zyxin
    Names
    CG32018-PA
    CG32018-PB
    CG32018-PG
    CG32018-PH
    CG32018-PL
    Zyx-PA
    Zyx-PB
    Zyx-PG
    Zyx-PH
    Zyx-PL
    Zyx102EF

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      1057365..1065001 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258501.3 → NP_001245430.1  zyxin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245430.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H9XVP5, Q5U0W6
      Conserved Domains (3) summary
      cd09351
      Location:299 → 352
      LIM1_LPP; The first LIM domain of lipoma preferred partner (LPP)
      cd09354
      Location:359 → 418
      LIM2_LPP; The second LIM domain of lipoma preferred partner (LPP)
      cd09437
      Location:419 → 486
      LIM3_LPP; The third LIM domain of lipoma preferred partner (LPP)

    2. NM_166819.3 → NP_726642.1  zyxin, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726642.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U0W6, Q9N675
      Related
      FBpp0311465
      Conserved Domains (3) summary
      cd09351
      Location:388 → 441
      LIM1_LPP; The first LIM domain of lipoma preferred partner (LPP)
      cd09354
      Location:448 → 507
      LIM2_LPP; The second LIM domain of lipoma preferred partner (LPP)
      cd09437
      Location:508 → 575
      LIM3_LPP; The third LIM domain of lipoma preferred partner (LPP)

    3. NM_166815.3 → NP_726638.1  zyxin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726638.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U0W6, Q8I0G8
      Related
      FBpp0088278
      Conserved Domains (3) summary
      cd09351
      Location:326 → 379
      LIM1_LPP; The first LIM domain of lipoma preferred partner (LPP)
      cd09354
      Location:386 → 445
      LIM2_LPP; The second LIM domain of lipoma preferred partner (LPP)
      cd09437
      Location:446 → 513
      LIM3_LPP; The third LIM domain of lipoma preferred partner (LPP)

    4. NM_166816.3 → NP_726639.1  zyxin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726639.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U0W6, Q8T0F5
      Related
      FBpp0088274
      Conserved Domains (3) summary
      cd09351
      Location:367 → 420
      LIM1_LPP; The first LIM domain of lipoma preferred partner (LPP)
      cd09354
      Location:427 → 486
      LIM2_LPP; The second LIM domain of lipoma preferred partner (LPP)
      cd09437
      Location:487 → 554
      LIM3_LPP; The third LIM domain of lipoma preferred partner (LPP)

    5. NM_143758.4 → NP_652015.1  zyxin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652015.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5U0W6, Q9N675
      Related
      FBpp0088275
      Conserved Domains (3) summary
      cd09351
      Location:388 → 441
      LIM1_LPP; The first LIM domain of lipoma preferred partner (LPP)
      cd09354
      Location:448 → 507
      LIM2_LPP; The second LIM domain of lipoma preferred partner (LPP)
      cd09437
      Location:508 → 575
      LIM3_LPP; The third LIM domain of lipoma preferred partner (LPP)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    H9XVP5 H9XVP5
    Q5U0W6 Q5U0W6
    Q8I0G8 Q8I0G8
    Q8T0F5 Q8T0F5
    Q9N675 Q9N675

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous