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    Kpc1 Kip1 ubiquitination-promoting complex subunit 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41826, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kpc1provided by FlyBase
    Official Full Name
    Kip1 ubiquitination-promoting complex subunit 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0038296
    Locus tag
    Dmel_CG6752
    See related
    AllianceGenome:FB:FBgn0038296
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6752; dKpc1; dKPC1; Dmel\CG6752
    Summary
    Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Predicted to be involved in proteolysis involved in protein catabolic process. Located in sperm flagellum. Part of ubiquitin ligase complex. Is expressed in adult head; embryonic brain; larval ventral nerve cord; organism; and ventral midline of embryo. Orthologous to human RNF123 (ring finger protein 123). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Kpc1 in Genome Data Viewer
    Location:
    88E2-88E2; 3-56 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15191058..15196210, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11016780..11021932, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Glycogen synthase Neighboring gene Guanylyl cyclase at 88E Neighboring gene Myofilin Neighboring gene mir-3644 stem loop Neighboring gene uncharacterized protein Neighboring gene Serpin 88Ea Neighboring gene Serpin 88Eb

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity  
    enables ubiquitin-protein transferase activity  
    enables ubiquitin-protein transferase activity  
    enables zinc ion binding PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in sperm flagellum PubMed 
    part_of ubiquitin ligase complex PubMed 

    General protein information

    Preferred Names
    Kip1 ubiquitination-promoting complex subunit 1
    Names
    CG6752-PA
    CG6752-PB
    Kpc1-PA
    Kpc1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15191058..15196210 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142168.2 → NP_650425.1  Kip1 ubiquitination-promoting complex subunit 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650425.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFC4
      Related
      FBpp0082488
      Conserved Domains (2) summary
      pfam13920
      Location:1261 → 1309
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cd12882
      Location:122 → 249
      SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123
    2. NM_001260187.1 → NP_001247116.1  Kip1 ubiquitination-promoting complex subunit 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247116.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFC4
      Conserved Domains (2) summary
      pfam13920
      Location:1261 → 1309
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cd12882
      Location:122 → 249
      SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123
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