Fbxl7 F-box and leucine-rich repeat protein 7 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Fbxl7provided by FlyBase
Official Full Name: F-box and leucine-rich repeat protein 7provided by FlyBase
Primary source: FLYBASE:FBgn0038385
Locus tag: Dmel_CG4221
See related: AllianceGenome:FB:FBgn0038385
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4221; Dmel\CG4221; fbxl7; FbxL7; FBXL7
Summary: Involved in several processes, including negative regulation of imaginal disc growth; positive regulation of hippo signaling; and proximal/distal pattern formation, imaginal disc. Located in apical part of cell and cell-cell junction. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including anterior endoderm anlage; clypeo-labral primordium; dorsal ectoderm anlage; imaginal disc; and mesoderm. Orthologous to human FBXL7 (F-box and leucine rich repeat protein 7). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (15920898..15932887)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (11746620..11758609)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Fbxl7 binds to the Ft protein and regulates Dachs localization and Hippo signaling.
Title: The Drosophila F-box protein Fbxl7 binds to the protocadherin fat and regulates Dachs localization and Hippo signaling.
Data proposes that Ft recruits FbxL7 to the proximal side of the cell to help restrict Ds and Dachs to the distal side of the cell.
Title: The ubiquitin ligase FbxL7 regulates the Dachsous-Fat-Dachs system in Drosophila.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISM Inferred from Sequence Model more info
involved_in negative regulation of growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of imaginal disc growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in proximal/distal pattern formation, imaginal disc	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of SCF ubiquitin ligase complex	ISM Inferred from Sequence Model more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed

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