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    ClpX Caseinolytic protease chaperone subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42369, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ClpXprovided by FlyBase
    Official Full Name
    Caseinolytic protease chaperone subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038745
    Locus tag
    Dmel_CG4538
    See related
    AllianceGenome:FB:FBgn0038745
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4538; Clpx; Dmel\CG4538
    Summary
    Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in proteolysis involved in protein catabolic process and regulation of mitochondrial gene expression. Part of mitochondrial endopeptidase Clp complex. Is expressed in adult heart; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in erythropoietic protoporphyria. Orthologous to human CLPX (caseinolytic mitochondrial matrix peptidase chaperone subunit X). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ClpX in Genome Data Viewer
    Location:
    92B4-92B6; 3-67 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19897372..19903689, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15723094..15729411, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Apoptotic signal-regulating kinase 1 Neighboring gene neither inactivation nor afterpotential E Neighboring gene uncharacterized protein Neighboring gene Rho GTPase activating protein at 92B Neighboring gene long non-coding RNA:CR45047 Neighboring gene Surfeit 6 Neighboring gene long non-coding RNA:CR45048

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A bidirectional relationship between sleep and oxidative stress in Drosophila. Hill VM, et al. PLoS Biol, 2018 Jul. PMID 30001323, Free PMC Article
    2. PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix. Thomas RE, et al. PLoS Genet, 2014. PMID 24874806, Free PMC Article
    3. Drosophila protease ClpXP specifically degrades DmLRPPRC1 controlling mitochondrial mRNA and translation. Matsushima Y, et al. Sci Rep, 2017 Aug 16. PMID 28814717, Free PMC Article
    4. Muscle mitohormesis promotes longevity via systemic repression of insulin signaling. Owusu-Ansah E, et al. Cell, 2013 Oct 24. PMID 24243023, Free PMC Article
    5. Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration. Yoon WH, et al. Neuron, 2017 Jan 4. PMID 28017472, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial protein quality control TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein folding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrial gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of mitochondrial endopeptidase Clp complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial matrix IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    caseinolytic protease chaperone subunit
    Names
    CG4538-PA
    CG4538-PC
    CG4538-PD
    ClpX-PA
    ClpX-PC
    ClpX-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19897372..19903689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300484.1 → NP_001287413.1  caseinolytic protease chaperone subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287413.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LID7
      Conserved Domains (3) summary
      smart01086
      Location:544 → 631
      ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
      COG1219
      Location:140 → 638
      ClpX; ATP-dependent protease Clp, ATPase subunit [Posttranslational modification, protein turnover, chaperones]
      pfam07724
      Location:327 → 537
      AAA_2; AAA domain (Cdc48 subfamily)

    2. NM_169880.2 → NP_732463.2  caseinolytic protease chaperone subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732463.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IN64, Q9VDS7
      Conserved Domains (3) summary
      smart01086
      Location:544 → 631
      ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
      COG1219
      Location:140 → 638
      ClpX; ATP-dependent protease Clp, ATPase subunit [Posttranslational modification, protein turnover, chaperones]
      pfam07724
      Location:327 → 537
      AAA_2; AAA domain (Cdc48 subfamily)

    3. NM_142586.2 → NP_650843.1  caseinolytic protease chaperone subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650843.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IN64, Q9VDS7
      Related
      FBpp0083264
      Conserved Domains (3) summary
      smart01086
      Location:544 → 631
      ClpB_D2-small; C-terminal, D2-small domain, of ClpB protein
      COG1219
      Location:140 → 638
      ClpX; ATP-dependent protease Clp, ATPase subunit [Posttranslational modification, protein turnover, chaperones]
      pfam07724
      Location:327 → 537
      AAA_2; AAA domain (Cdc48 subfamily)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LID7 A0A0B4LID7
    Q960M5 Q960M5
    Q9VDS7 Q9VDS7

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