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    Txnrd1 thioredoxin reductase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58819, updated on 9-Dec-2024

    Summary

    Official Symbol
    Txnrd1provided by RGD
    Official Full Name
    thioredoxin reductase 1provided by RGD
    Primary source
    RGD:61959
    See related
    EnsemblRapid:ENSRNOG00000009088 AllianceGenome:RGD:61959
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tr
    Summary
    The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms. [provided by RefSeq, Jun 2017]
    Expression
    Biased expression in Kidney (RPKM 368.7), Liver (RPKM 218.2) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Txnrd1 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (22717620..22802553, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (20830042..20914990, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (26946124..26984400, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 11 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134479651 Neighboring gene uncharacterized LOC134479652 Neighboring gene uncharacterized LOC108351425 Neighboring gene uncharacterized LOC134479653 Neighboring gene EP300 interacting inhibitor of differentiation 3 Neighboring gene uncharacterized LOC103692815 Neighboring gene nuclear transcription factor Y subunit beta

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC93353

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FAD binding  
    enables FAD binding  
    enables FAD binding  
    enables NAD(P)H oxidase H2O2-forming activity PubMed 
    enables NADPH peroxidase activity PubMed 
    enables NADPH peroxidase activity  
    enables NADPH peroxidase activity  
    enables identical protein binding  
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables mercury ion binding PubMed 
    enables selenate reductase activity PubMed 
    enables thioredoxin-disulfide reductase (NADPH) activity  
    enables thioredoxin-disulfide reductase (NADPH) activity PubMed 
    enables thioredoxin-disulfide reductase (NADPH) activity  
    enables thioredoxin-disulfide reductase (NADPH) activity  
    Process Evidence Code Pubs
    involved_in NADPH oxidation PubMed 
    involved_in benzene-containing compound metabolic process PubMed 
    acts_upstream_of_or_within cell population proliferation  
    involved_in cell redox homeostasis  
    involved_in cell redox homeostasis  
    involved_in cellular oxidant detoxification  
    involved_in cellular response to copper ion PubMed 
    involved_in cellular response to hyperoxia PubMed 
    acts_upstream_of_or_within gastrulation  
    involved_in halogen metabolic process PubMed 
    involved_in hydrogen peroxide catabolic process PubMed 
    acts_upstream_of_or_within mesoderm formation  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in response to axon injury PubMed 
    involved_in response to hyperoxia PubMed 
    involved_in response to oxidative stress PubMed 
    involved_in response to oxidative stress  
    involved_in response to selenium ion PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in selenocysteine metabolic process PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in fibrillar center  
    located_in fibrillar center  
    is_active_in mitochondrion  
    located_in neuronal cell body PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    thioredoxin reductase 1, cytoplasmic
    Names
    NADPH-dependent thioredoxin reductase
    peroxidase TXNRD1
    selenoprotein oxidoreductase
    thioredoxin reductase TR1
    NP_001338910.1
    NP_001338912.1
    NP_001338913.1
    NP_113802.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351981.1NP_001338910.1  thioredoxin reductase 1, cytoplasmic isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a 5' non-coding exon; therefore, has a shorter 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      AF220761, BC085726, BF415095, CB579100
      UniProtKB/Swiss-Prot
      O89049, Q5U344, Q9JKZ3, Q9JKZ4, Q9R1I3
      UniProtKB/TrEMBL
      R9PXU4
      Related
      ENSRNOP00000013612.9, ENSRNOT00000013613.9
      Conserved Domains (1) summary
      TIGR01438
      Location:11499
      TGR; thioredoxin and glutathione reductase selenoprotein
    2. NM_001351983.1NP_001338912.1  thioredoxin reductase 1, cytoplasmic isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
      Source sequence(s)
      BC085726, BF415095, FQ090798, FQ225805
      UniProtKB/Swiss-Prot
      O89049, Q5U344, Q9JKZ3, Q9JKZ4, Q9R1I3
      UniProtKB/TrEMBL
      R9PXU4
      Conserved Domains (1) summary
      TIGR01438
      Location:11499
      TGR; thioredoxin and glutathione reductase selenoprotein
    3. NM_001351984.1NP_001338913.1  thioredoxin reductase 1, cytoplasmic isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents use of an alternate upstream promoter, and contains additional exons at the 5' end compared to variant 1. The encoded isoform (2) has a longer and distinct N-terminus, resulting from translation initiation at an in-frame upstream start codon, compared to isoform 1.
      Source sequence(s)
      BC085726, BF415095
      UniProtKB/Swiss-Prot
      O89049, Q5U344, Q9JKZ3, Q9JKZ4, Q9R1I3
      UniProtKB/TrEMBL
      R9PXU4
      Conserved Domains (1) summary
      TIGR01438
      Location:92580
      TGR; thioredoxin and glutathione reductase selenoprotein
    4. NM_031614.3NP_113802.2  thioredoxin reductase 1, cytoplasmic isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1. Variants 1-3 encode the same isoform.
      Source sequence(s)
      BC085726, BF415095, CB579100
      UniProtKB/Swiss-Prot
      O89049, Q5U344, Q9JKZ3, Q9JKZ4, Q9R1I3
      UniProtKB/TrEMBL
      R9PXU4
      Conserved Domains (1) summary
      TIGR01438
      Location:11499
      TGR; thioredoxin and glutathione reductase selenoprotein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      22717620..22802553 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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