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    Sf3b2 splicing factor 3b, subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 293671, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sf3b2provided by RGD
    Official Full Name
    splicing factor 3b, subunit 2provided by RGD
    Primary source
    RGD:1307159
    See related
    EnsemblRapid:ENSRNOG00000020412 AllianceGenome:RGD:1307159
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SAP145
    Summary
    Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP and spliceosomal complex. Human ortholog(s) of this gene implicated in Goldenhar syndrome. Orthologous to human SF3B2 (splicing factor 3b subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 315.4), Lung (RPKM 268.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Sf3b2 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (211999777..212040686, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202570423..202590774, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (220645685..220665611, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120099980 Neighboring gene phosphofurin acidic cluster sorting protein 1 Neighboring gene F11 receptor, pseudogene 1 Neighboring gene galactose-3-O-sulfotransferase 3 Neighboring gene cation channel, sperm associated 1 Neighboring gene cystatin E/M

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process  
    involved_in mRNA splicing, via spliceosome  
    involved_in mRNA splicing, via spliceosome  
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex  
    part_of U12-type spliceosomal complex  
    part_of U2 snRNP  
    part_of U2-type precatalytic spliceosome  
    part_of U2-type spliceosomal complex  
    part_of U2-type spliceosomal complex  
    part_of catalytic step 2 spliceosome  
    part_of catalytic step 2 spliceosome  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleus  
    part_of precatalytic spliceosome  
    part_of spliceosomal complex  

    General protein information

    Preferred Names
    splicing factor 3B subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106326.1NP_001099796.2  splicing factor 3B subunit 2

      See identical proteins and their annotated locations for NP_001099796.2

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A0A8I6A8Y6, A6HZ38, D3ZMS1
      Related
      ENSRNOP00000060335.3, ENSRNOT00000068497.5
      Conserved Domains (3) summary
      smart00581
      Location:584642
      PSP; proline-rich domain in spliceosome associated proteins
      pfam02037
      Location:2457
      SAP; SAP domain
      pfam04037
      Location:454579
      DUF382; Domain of unknown function (DUF382)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      211999777..212040686 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286842.1XP_063142912.1  splicing factor 3B subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8Y6, A6HZ38, D3ZMS1
    2. XM_063286841.1XP_063142911.1  splicing factor 3B subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8Y6, A6HZ38, D3ZMS1
    3. XM_008760105.4XP_008758327.2  splicing factor 3B subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A8Y6
      Conserved Domains (3) summary
      COG5182
      Location:424688
      CUS1; Splicing factor 3b, subunit 2 [RNA processing and modification]
      pfam02037
      Location:2457
      SAP; SAP domain
      pfam04037
      Location:453578
      DUF382; Domain of unknown function (DUF382)
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