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    Ddx47 DEAD-box helicase 47 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297685, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ddx47provided by RGD
    Official Full Name
    DEAD-box helicase 47provided by RGD
    Primary source
    RGD:1310437
    See related
    EnsemblRapid:ENSRNOG00000007838 AllianceGenome:RGD:1310437
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including ATP binding activity; RNA helicase activity; and nucleic acid binding activity. Predicted to be involved in RNA splicing; extrinsic apoptotic signaling pathway via death domain receptors; and rRNA processing. Predicted to be located in nucleolus. Predicted to be active in nucleus. Orthologous to human DDX47 (DEAD-box helicase 47). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 240.3), Lung (RPKM 213.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ddx47 in Genome Data Viewer
    Location:
    4q43
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (169577013..169589473)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (167845652..167858115)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (168775134..168787594)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase inhibitor 1B Neighboring gene apolipoprotein L domain containing 1 Neighboring gene proteasome maturation protein pseudogene Neighboring gene G protein-coupled receptor, class C, group 5, member A Neighboring gene G protein-coupled receptor, class C, group 5, member D

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC105650

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables RNA helicase activity  
    enables hydrolase activity  
    enables nucleic acid binding  
    Process Evidence Code Pubs
    involved_in RNA splicing  
    involved_in extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in rRNA processing  
    involved_in rRNA processing  
    Component Evidence Code Pubs
    located_in nucleolus  
    located_in nucleolus  
    is_active_in nucleus  

    General protein information

    Preferred Names
    probable ATP-dependent RNA helicase DDX47
    Names
    DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
    NP_001015005.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015005.2NP_001015005.2  probable ATP-dependent RNA helicase DDX47

      See identical proteins and their annotated locations for NP_001015005.2

      Status: VALIDATED

      Source sequence(s)
      BC091696, CB761683
      UniProtKB/TrEMBL
      A0A8I5ZKX7, A6IMF0
      Related
      ENSRNOP00000078347.2, ENSRNOT00000095905.2
      Conserved Domains (3) summary
      PRK11192
      Location:24446
      PRK11192; ATP-dependent RNA helicase SrmB; Provisional
      cd00079
      Location:237366
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:26227
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      169577013..169589473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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