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    Slc26a4 solute carrier family 26 member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29440, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc26a4provided by RGD
    Official Full Name
    solute carrier family 26 member 4provided by RGD
    Primary source
    RGD:3293
    See related
    EnsemblRapid:ENSRNOG00000058692 AllianceGenome:RGD:3293
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pds
    Summary
    Enables chloride:bicarbonate antiporter activity and iodide transmembrane transporter activity. Involved in inorganic anion transport. Located in apical plasma membrane. Human ortholog(s) of this gene implicated in Pendred Syndrome; autosomal recessive nonsyndromic deafness 4; and goiter. Orthologous to human SLC26A4 (solute carrier family 26 member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Uterus (RPKM 152.1) and Kidney (RPKM 135.1) See more
    Orthologs
    NEW
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    Genomic context

    See Slc26a4 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (53835102..53873968, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (48107575..48153762, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (50809103..50848443, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 26 member 3 Neighboring gene uncharacterized LOC102555378 Neighboring gene Cbl proto-oncogene like 1 Neighboring gene uncharacterized LOC108351220 Neighboring gene B-cell receptor-associated protein 29

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in bicarbonate transport  
    involved_in chloride transmembrane transport  
    involved_in inorganic anion transport PubMed 
    involved_in iodide transport  
    involved_in oxalate transport  
    involved_in regulation of pH  
    involved_in regulation of pH  
    involved_in regulation of protein localization  
    involved_in regulation of protein localization  
    involved_in sulfate transmembrane transport  
    Component Evidence Code Pubs
    located_in apical plasma membrane PubMed 
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in brush border membrane  
    located_in brush border membrane  
    located_in extracellular exosome  
    located_in membrane  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    pendrin
    Names
    Pendred syndrome homolog
    sodium-independent chloride/iodide transporter
    solute carrier family 26 (anion exchanger), member 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019214.1NP_062087.1  pendrin

      See identical proteins and their annotated locations for NP_062087.1

      Status: PROVISIONAL

      Source sequence(s)
      AF167412
      UniProtKB/Swiss-Prot
      Q9R154
      UniProtKB/TrEMBL
      A6HB50, A6HB51
      Related
      ENSRNOP00000070261.1, ENSRNOT00000087300.3
      Conserved Domains (1) summary
      TIGR00815
      Location:70725
      sulP; high affinity sulphate transporter 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      53835102..53873968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017594054.3XP_017449543.1  pendrin isoform X1

      UniProtKB/Swiss-Prot
      Q9R154
      UniProtKB/TrEMBL
      A6HB50, A6HB51
      Conserved Domains (1) summary
      TIGR00815
      Location:70725
      sulP; high affinity sulphate transporter 1
    2. XM_008764576.4XP_008762798.1  pendrin isoform X1

      See identical proteins and their annotated locations for XP_008762798.1

      UniProtKB/Swiss-Prot
      Q9R154
      UniProtKB/TrEMBL
      A6HB50, A6HB51
      Conserved Domains (1) summary
      TIGR00815
      Location:70725
      sulP; high affinity sulphate transporter 1
    3. XM_008764577.4XP_008762799.1  pendrin isoform X2

      UniProtKB/TrEMBL
      A6HB50
      Conserved Domains (2) summary
      cd07042
      Location:448634
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      TIGR00815
      Location:12637
      sulP; high affinity sulphate transporter 1
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