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    Dpp4 dipeptidylpeptidase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25253, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dpp4provided by RGD
    Official Full Name
    dipeptidylpeptidase 4provided by RGD
    Primary source
    RGD:2515
    See related
    EnsemblRapid:ENSRNOG00000030763 AllianceGenome:RGD:2515
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CD26; DPPIV
    Summary
    Enables several functions, including collagen binding activity; dipeptidyl-peptidase activity; and identical protein binding activity. Involved in B-1a B cell differentiation; protein catabolic process; and regulation of lymphocyte mediated immunity. Located in cell surface. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 1492.6), Liver (RPKM 372.0) and 3 other tissues See more
    Orthologs
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    Genomic context

    See Dpp4 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (67370794..67452422, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (46962233..47043870, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (48291055..48372672, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L9, pseudogene 12 Neighboring gene solute carrier family 4 member 10 Neighboring gene uncharacterized LOC134486365 Neighboring gene uncharacterized LOC120101554 Neighboring gene uncharacterized LOC103691814 Neighboring gene glucagon

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminopeptidase activity  
    enables chemorepellent activity  
    enables collagen binding PubMed 
    enables dipeptidyl-peptidase activity  
    enables dipeptidyl-peptidase activity PubMed 
    enables dipeptidyl-peptidase activity  
    enables dipeptidyl-peptidase activity PubMed 
    enables dipeptidyl-peptidase activity  
    enables dipeptidyl-peptidase activity  
    enables identical protein binding PubMed 
    enables identical protein binding PubMed 
    enables identical protein binding  
    enables peptide binding PubMed 
    enables protease binding  
    enables protease binding  
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables serine-type endopeptidase activity  
    enables serine-type endopeptidase activity  
    enables serine-type peptidase activity  
    enables signaling receptor binding  
    enables signaling receptor binding  
    enables virus receptor activity  
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in B-1a B cell differentiation PubMed 
    involved_in T cell activation  
    involved_in T cell costimulation  
    involved_in T cell costimulation  
    acts_upstream_of_or_within behavioral fear response  
    involved_in cell adhesion  
    involved_in endothelial cell migration  
    involved_in endothelial cell migration  
    acts_upstream_of_or_within locomotory exploration behavior  
    involved_in negative chemotaxis  
    involved_in negative regulation of extracellular matrix disassembly  
    involved_in negative regulation of extracellular matrix disassembly  
    involved_in negative regulation of neutrophil chemotaxis  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of natural killer cell mediated immunity PubMed 
    involved_in protein catabolic process PubMed 
    involved_in proteolysis  
    involved_in proteolysis  
    involved_in proteolysis  
    involved_in proteolysis PubMed 
    acts_upstream_of_or_within psychomotor behavior  
    involved_in regulation of T cell mediated immunity PubMed 
    involved_in regulation of cell-cell adhesion mediated by integrin  
    involved_in response to hypoxia  
    involved_in symbiont entry into host cell  
    Items 1 - 25 of 26
    Component Evidence Code Pubs
    located_in anchoring junction  
    located_in apical plasma membrane  
    located_in apical plasma membrane  
    located_in cell surface PubMed 
    located_in cell surface  
    located_in cell surface  
    located_in endocytic vesicle  
    located_in endocytic vesicle  
    located_in extracellular region  
    located_in intercellular canaliculus  
    located_in lamellipodium  
    located_in lamellipodium  
    located_in lamellipodium membrane  
    located_in membrane raft  
    is_active_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    dipeptidyl peptidase 4
    Names
    DPP IV
    GP110 glycoprotein
    T-cell activation antigen CD26
    bile canaliculus domain-specific membrane glycoprotein
    dipeptidyl peptidase IV
    NP_036921.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012789.2NP_036921.2  dipeptidyl peptidase 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      P14740
      UniProtKB/TrEMBL
      A6HLV5
      Related
      ENSRNOP00000068881.2, ENSRNOT00000085426.3
      Conserved Domains (3) summary
      pfam00326
      Location:560764
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:106479
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      pfam18811
      Location:3656
      DPPIV_rep; Dipeptidyl peptidase IV (DPP IV) low complexity region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      67370794..67452422 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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