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    Opa3 outer mitochondrial membrane lipid metabolism regulator OPA3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308409, updated on 9-Dec-2024

    Summary

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    Symbol
    Opa3provided by RGD
    Full Name
    outer mitochondrial membrane lipid metabolism regulator OPA3provided by RGD
    Primary source
    RGD:1309147
    See related
    EnsemblRapid:ENSRNOG00000064373 AllianceGenome:RGD:1309147
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in visual perception. Predicted to act upstream of or within several processes, including bone development; fat cell differentiation; and neuromuscular process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 3 and optic atrophy 3. Orthologous to human OPA3 (outer mitochondrial membrane lipid metabolism regulator OPA3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 177.8), Muscle (RPKM 132.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Opa3 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (88007707..88037639)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (78879612..78910453)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80141630..80160145)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene EMAP like 2 Neighboring gene microRNA 330 Neighboring gene G protein-coupled receptor 4 Neighboring gene vasodilator-stimulated phosphoprotein Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1N

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Opa3, a novel regulator of mitochondrial function, controls thermogenesis and abdominal fat mass in a mouse model for Costeff syndrome. Wells T, et al. Hum Mol Genet, 2012 Nov 15. PMID 22869679
    2. OPA3 gene mutations responsible for autosomal dominant optic atrophy and cataract. Reynier P, et al. J Med Genet, 2004 Sep. PMID 15342707, Free PMC Article
    3. A missense mutation in the murine Opa3 gene models human Costeff syndrome. Davies VJ, et al. Brain, 2008 Feb. PMID 18222992
    4. Mitochondrial localization and ocular expression of mutant Opa3 in a mouse model of 3-methylglutaconicaciduria type III. Powell KA, et al. Invest Ophthalmol Vis Sci, 2011 Jun 21. PMID 21613372
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within bone development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in visual perception ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    optic atrophy 3 protein
    Names
    OPA3, outer mitochondrial membrane lipid metabolism regulator
    optic atrophy 3 protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399653.1 → NP_001386582.1  optic atrophy 3 protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      88007707..88037639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589999.3 → XP_017445488.2  optic atrophy 3 protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQB7, A0A8I6AQX4
      Related
      ENSRNOP00000097116.1, ENSRNOT00000099247.2
      Conserved Domains (1) summary
      pfam07047
      Location:6 → 129
      OPA3; Optic atrophy 3 protein (OPA3)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107486.1: Suppressed sequence

      Description
      NM_001107486.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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