Tmed10 transmembrane p24 trafficking protein 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmed10provided by RGD
Official Full Name: transmembrane p24 trafficking protein 10provided by RGD
Primary source: RGD:620970
See related: EnsemblRapid:ENSRNOG00000007901 AllianceGenome:RGD:620970
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmp21
Summary: Predicted to enable protein transmembrane transporter activity and syntaxin binding activity. Involved in several processes, including Golgi organization; response to alkaloid; and vesicle targeting, to, from or within Golgi. Located in several cellular components, including Golgi apparatus; cytoplasmic vesicle; and endoplasmic reticulum-Golgi intermediate compartment. Part of gamma-secretase complex. Orthologous to human TMED10 (transmembrane p24 trafficking protein 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 658.1), Kidney (RPKM 657.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q31

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (110722887..110757743, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (104991843..105026705, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (109169739..109205004, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

chondrocyte-associated antigen Tmp21 may be considered a chondrocyte differentiation antigen
Title: Rat chondrocyte-associated antigen identified as sialylated transmembrane protein Tmp21 belonging to the p24 protein family.
p23 is expressed in neurons throughout the brain; the decline in p23 expression during postnatal development may significantly contribute to enhanced beta-amyloid production in the adult brain.
Title: Localization and regional distribution of p23/TMP21 in the brain.
These findings suggest that a fraction of p23 enters post-Golgi compartments and may function in the biogenesis and/or quality control of SGs.
Title: A subset of p23 localized on secretory granules in pancreatic beta-cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139915 (e-PCR)
- UniSTS:221999

RH130037 (e-PCR)
- UniSTS:213325

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables protein transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables syntaxin binding	IEA Inferred from Electronic Annotation more info
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in COPI-coated vesicle budding	IEA Inferred from Electronic Annotation more info
involved_in COPI-coated vesicle budding	ISO Inferred from Sequence Orthology more info
involved_in COPI-coated vesicle budding	ISS Inferred from Sequence or Structural Similarity more info
involved_in Golgi organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in Golgi organization	IEA Inferred from Electronic Annotation more info
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in cytosol to ERGIC protein transport	IEA Inferred from Electronic Annotation more info
involved_in cytosol to ERGIC protein transport	ISO Inferred from Sequence Orthology more info
involved_in cytosol to ERGIC protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	NAS Non-traceable Author Statement more info	PubMed
involved_in intracellular protein transport	TAS Traceable Author Statement more info	PubMed
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to ERGIC	IEA Inferred from Electronic Annotation more info
involved_in protein localization to ERGIC	ISO Inferred from Sequence Orthology more info
involved_in protein localization to ERGIC	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulated exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulated exocytosis	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulated exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid-beta formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to alkaloid	IEP Inferred from Expression Pattern more info	PubMed
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
involved_in vesicle targeting	NAS Non-traceable Author Statement more info	PubMed
involved_in vesicle targeting, to, from or within Golgi	IEP Inferred from Expression Pattern more info	PubMed
involved_in vesicle targeting, to, from or within Golgi	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in COPI-coated vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in COPI-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in COPII-coated ER to Golgi transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cis-Golgi network	IDA Inferred from Direct Assay more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum-Golgi intermediate compartment	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum-Golgi intermediate compartment	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
part_of gamma-secretase complex	IDA Inferred from Direct Assay more info	PubMed
part_of gamma-secretase complex	IEA Inferred from Electronic Annotation more info
part_of gamma-secretase complex	ISO Inferred from Sequence Orthology more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule membrane	ISO Inferred from Sequence Orthology more info
located_in secretory granule membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network transport vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in zymogen granule membrane	IDA Inferred from Direct Assay more info	PubMed
located_in zymogen granule membrane	IEA Inferred from Electronic Annotation more info
located_in zymogen granule membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane emp24 domain-containing protein 10

Names: 21 kDa transmembrane-trafficking protein; integral membrane protein Tmp21-I (p23); p24 family protein delta-1; p24delta1; transmembrane emp24-like trafficking protein 10; transmembrane protein Tmp21; transmembrane trafficking protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.