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    Dars2 aspartyl-tRNA synthetase 2 (mitochondrial) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304919, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dars2provided by RGD
    Official Full Name
    aspartyl-tRNA synthetase 2 (mitochondrial)provided by RGD
    Primary source
    RGD:1308286
    See related
    EnsemblRapid:ENSRNOG00000002813 AllianceGenome:RGD:1308286
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308286
    Summary
    Predicted to enable aspartate-tRNA ligase activity; aspartate-tRNA(Asn) ligase activity; and protein homodimerization activity. Predicted to be involved in aspartyl-tRNA aminoacylation and mitochondrial asparaginyl-tRNA aminoacylation. Predicted to be located in mitochondrial matrix; mitochondrial membrane; and nucleoplasm. Predicted to be active in mitochondrion. Orthologous to human DARS2 (aspartyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 113.7), Kidney (RPKM 108.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dars2 in Genome Data Viewer
    Location:
    13q22
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (75842078..75870319, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (73308726..73336558, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (78857638..78885464, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD47 Neighboring gene growth arrest specific 5 Neighboring gene Small nucleolar RNA SNORD81 Neighboring gene centromere protein L Neighboring gene ribosomal protein S10-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Thermodynamic properties distinguish human mitochondrial aspartyl-tRNA synthetase from bacterial homolog with same 3D architecture. Neuenfeldt A, et al. Nucleic Acids Res, 2013 Feb 1. PMID 23275545, Free PMC Article
    2. Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation. Scheper GC, et al. Nat Genet, 2007 Apr. PMID 17384640
    3. Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. Bonnefond L, et al. Biochemistry, 2005 Mar 29. PMID 15779907
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124683

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartate-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartate-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables aspartate-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables aspartate-tRNA(Asn) ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in aspartyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial asparaginyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial asparaginyl-tRNA aminoacylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aspartate--tRNA ligase, mitochondrial
    Names
    aspRS
    aspartyl-tRNA synthetase, mitochondrial
    NP_001029315.1
    XP_063128429.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034143.2 → NP_001029315.1  aspartate--tRNA ligase, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001029315.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q3KRD0
      UniProtKB/TrEMBL
      A6ID72
      Related
      ENSRNOP00000003828.5, ENSRNOT00000003828.8
      Conserved Domains (4) summary
      PRK00476
      Location:49 → 635
      aspS; aspartyl-tRNA synthetase; Validated
      cd00777
      Location:186 → 606
      AspRS_core; Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the ...
      cd04317
      Location:49 → 182
      EcAspRS_like_N; EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND) ...
      pfam02938
      Location:360 → 451
      GAD; GAD domain

    2. NM_001430110.1 → NP_001417039.1  aspartate--tRNA ligase, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6AQH7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      75842078..75870319 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272359.1 → XP_063128429.1  aspartate--tRNA ligase, mitochondrial isoform X1

      Related
      ENSRNOP00000096359.1, ENSRNOT00000108708.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KRD0.1 GenPept UniProtKB/Swiss-Prot:Q3KRD0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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